Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK.
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
Cell Rep. 2023 Jan 31;42(1):111952. doi: 10.1016/j.celrep.2022.111952. Epub 2023 Jan 4.
Sensory processing is crucial for execution of appropriate behavior. The external globus pallidus (GPe), a nucleus within the basal ganglia, is highly involved in the control of movement and could potentially integrate sensory-motor information. The GPe comprises prototypic and arkypallidal cells, which receive partially overlapping inputs. It is unclear, however, which inputs convey sensory information to them. Here, we used in vivo whole-cell recordings in the mouse GPe and optogenetic silencing to characterize the pathways that shape the response to whisker stimulation in prototypic and arkypallidal cells. Our results show that sensory integration in prototypic cells is controlled by the subthalamic nucleus and indirect pathway medium spiny neurons (MSNs), whereas in arkypallidal cells, it is primarily shaped by direct pathway MSNs. These results suggest that GPe subpopulations receive sensory information from largely different neural populations, reinforcing that the GPe consists of two parallel pathways, which differ anatomically and functionally.
感觉处理对于执行适当的行为至关重要。基底神经节中的外部苍白球（GPe）高度参与运动的控制，并可能整合感觉运动信息。GPe 由原型和弓状苍白球细胞组成，它们接收部分重叠的输入。然而，尚不清楚哪些输入将感觉信息传递给它们。在这里，我们使用了在小鼠 GPe 中的体内全细胞记录和光遗传沉默技术，以表征塑造原型和弓状苍白球细胞对胡须刺激反应的途径。我们的结果表明，原型细胞中的感觉整合受丘脑底核和间接通路中间神经元（MSNs）控制，而在弓状苍白球细胞中，主要由直接通路 MSNs 塑造。这些结果表明，GPe 亚群从很大程度上不同的神经元群体接收感觉信息，这进一步证实了 GPe 由两个平行的通路组成，它们在解剖和功能上存在差异。
