孕期肥胖与巨噬细胞浸润以及蜕膜中GRO-α和IL-6表达上调有关。
Obesity in pregnancy is associated with macrophage influx and an upregulated GRO-alpha and IL-6 expression in the decidua.
作者信息
Löb Sanja, Knabl Julia, Vattai Aurelia, Schmoeckel Elisa, Kuhn Christina, Mittelberger Johanna, Wöckel Achim, Mahner Sven, Jeschke Udo
机构信息
Department of Obstetrics and Gynecology, University Hospital, University of Wuerzburg, Josef-Schneider-Str. 4, 97080 Würzburg, Germany.
Department of Obstetrics, Klinik Hallerwiese, Sankt-Johannis-Mühlgasse 19, 90419 Nürnberg, Germany; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Maistrasse 11, 80337 Munich, Germany.
出版信息
J Reprod Immunol. 2023 Mar;156:103800. doi: 10.1016/j.jri.2023.103800. Epub 2023 Jan 11.
About one third of all reproductive-aged women are affected by obesity. Maternal obesity is linked to an adverse outcome for both mother and child. The expression of the pro-inflammatory IL-6 and GRO-alpha as well as the infiltration of macrophages in the placenta of obese, non-diabetic pregnancies was examined by immunohistochemistry in comparison to the placenta of normal weight women. In obese pregnancies the influx of macrophages was significantly increased (p = 0.012). The protein expression of IL-6 and GRO-alpha was significantly elevated (p = 0.036 and p < 0.001, respectively) in the decidua of adipose females.
约三分之一的育龄妇女受肥胖影响。母亲肥胖与母婴不良结局相关。通过免疫组织化学检查肥胖非糖尿病孕妇胎盘与正常体重妇女胎盘相比促炎细胞因子白细胞介素-6（IL-6）和生长调节致癌基因α（GRO-α）的表达以及巨噬细胞浸润情况。在肥胖孕妇中，巨噬细胞流入显著增加（p = 0.012）。脂肪女性蜕膜中IL-6和GRO-α的蛋白表达显著升高（分别为p = 0.036和p < 0.001）。
Zotero 插件