Gerlai Robert
Department of Psychology, Rm CCT4004, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, Ontario L5L 1C6, Canada.
Neurosci Biobehav Rev. 2023 Jan;144:104978. doi: 10.1016/j.neubiorev.2022.104978. Epub 2022 Nov 26.
Behavioral neuroscience is an interdisciplinary field aimed at understanding the neurobiology of behavior. Numerous investigators turn to animals to model and understand the mechanisms underlying vertebrate brain function including human brain disorders, species that share evolutionary history with us. The zebrafish is a relatively new study species for such purposes. However, as this review attempts to demonstrate, it will likely have a good future in behavioral neuroscience. It is a simple vertebrate that is small and cheap to keep and study in the laboratory. Yet, it is similar enough to our own species, thus, we are able to use it for both translational as well as basic research. In this invited review, I will discuss its advantages and some of its disadvantages, the reasons and counterarguments why it should or should not be employed in research. I will focus on its utility in behavioral neuroscience, and will also provide a brief historical account of the evolution between zebrafish research and the science represented by the International Behavioral Neuroscience Society.
行为神经科学是一个跨学科领域，旨在理解行为的神经生物学机制。许多研究人员借助动物来建立模型并理解脊椎动物脑功能（包括人类脑部疾病）背后的机制，这些动物与我们有着共同的进化史。斑马鱼是用于此类研究目的的一个相对较新的研究物种。然而，正如本综述试图表明的那样，它在行为神经科学领域可能会有很好的前景。它是一种简单的脊椎动物，在实验室中饲养和研究成本低、规模小。然而，它与我们人类足够相似，因此我们能够将其用于转化研究和基础研究。在这篇特邀综述中，我将讨论其优点和一些缺点，以及在研究中使用或不使用它的理由和反对观点。我将重点关注其在行为神经科学中的实用性，还将简要介绍斑马鱼研究与国际行为神经科学学会所代表的科学之间的发展历程。
