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海洋放线菌产生的黑色素的抗氧化活性。

Antioxidant activities from melanin pigment produced by marine actinobacterium of species.

作者信息

Sheefaa M I, Sivaperumal Pitchiah

机构信息

Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Cellular and Molecular Research Centre, Marine Biomedical Research Laboratory and Environmental Toxicology Unit, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

出版信息

J Adv Pharm Technol Res. 2022 Nov;13(Suppl 1):S84-S87. doi: 10.4103/japtr.japtr_338_22. Epub 2022 Nov 30.

DOI:10.4103/japtr.japtr_338_22
PMID:36643127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9836102/
Abstract

Melanin is macromolecules which have been developed while oxidative polymerization of phenolic compounds. It has been found that the majority of marine organisms produce melanin pigment. To obtain the melanin from marine actinobacteria and their biological properties are studied. Isolation and identification of marine actinobacteria were carried out using the media of ISP-1, ISP-7. Spore chain morphology, chemotaxonomic characteristics were also analyzed by the International Project. The antioxidant activities of DPPH, lipid peroxide using actinobacterial melanin were determined. The species have the capacity to produce melanin pigments and it shows potential antioxidant properties. When DPPH concentrations were compared with the ascorbic acid standard, the melanin of 150 μg/ml showed 93.47% of scavenging. The present study was concluded that melanin pigment obtained from marine actinobacterium of species has potential antioxidant activities and these components might be useful to pharmaceutical industries.

摘要

黑色素是酚类化合物氧化聚合过程中形成的大分子。已发现大多数海洋生物会产生黑色素。为了从海洋放线菌中获取黑色素并研究其生物学特性。使用ISP - 1、ISP - 7培养基对海洋放线菌进行分离和鉴定。还通过国际项目分析了孢子链形态、化学分类特征。测定了放线菌黑色素对DPPH、脂质过氧化物的抗氧化活性。这些物种具有产生黑色素的能力，并显示出潜在的抗氧化特性。当将DPPH浓度与抗坏血酸标准品进行比较时，150μg/ml的黑色素显示出93.47%的清除率。本研究得出结论，从该物种的海洋放线菌中获得的黑色素具有潜在的抗氧化活性，这些成分可能对制药行业有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/f39def7929ca/JAPTR-13-84-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/39abac42c3d6/JAPTR-13-84-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/da195a6078e7/JAPTR-13-84-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/f39def7929ca/JAPTR-13-84-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/39abac42c3d6/JAPTR-13-84-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/da195a6078e7/JAPTR-13-84-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12fd/9836102/f39def7929ca/JAPTR-13-84-g003.jpg

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