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来自沉积物相关海洋放线菌的黑色素色素及其抗菌潜力。

Melanin pigments from sediment-associated sp. marine actinobacterium and antibacterial potential.

作者信息

Sundar R, Sivaperumal Pitchiah

机构信息

Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University, Chennai, Tamil Nadu, India.

Cellular and Molecular Research Centre, Marine Biomedical Research Lab and Environmental Toxicology Unit, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University, Chennai, Tamil Nadu, India.

出版信息

J Adv Pharm Technol Res. 2022 Nov;13(Suppl 1):S88-S92. doi: 10.4103/japtr.japtr_339_22. Epub 2022 Nov 30.

Abstract

To extract the melanin pigment from marine microbes and their biological potential, the present study was done. Isolation and identification of the melanin-producing sp. were obtained from the sediment samples. Zone of inhibition and minimal inhibitory concentration test was performed using melanin. Melanin was extracted from sediment-associated marine sp. In the present study, marine actinobacterium was identified by the conventional method, and the isolate was identified as sp. Melanin was extracted, and antibacterial activities were performed against different pathogens and the highest zone of inhibition is more in the while related to another two species. From previous observation done by Fu ., they have said that marine actinobacteria have the ability of antimicrobial activity, which is very much helpful in producing the potential antimicrobial drugs this was similar to our study that marine actinobacteria have the capability to produce melanin pigment, and at the same time, it helps as to show the antibacterial activity. We concluded that melanin is produced by the sp. We also found that melanin extracted from the sp. of marine actinobacterium also has an antibacterial effect.

摘要

为了从海洋微生物中提取黑色素及其生物潜力,开展了本研究。从沉积物样本中获得了产黑色素菌株的分离和鉴定。使用黑色素进行了抑菌圈和最低抑菌浓度测试。黑色素从与沉积物相关的海洋菌株中提取。在本研究中,通过传统方法鉴定了海洋放线菌,该分离株被鉴定为某菌株。提取了黑色素,并对不同病原体进行了抗菌活性测试,与另外两个物种相比,某菌株的抑菌圈最大。根据傅等人之前的观察,他们表示海洋放线菌具有抗菌活性,这对生产潜在的抗菌药物非常有帮助,这与我们的研究相似,即海洋放线菌有能力产生黑色素,同时,它有助于表现出抗菌活性。我们得出结论,黑色素由某菌株产生。我们还发现,从海洋放线菌某菌株中提取的黑色素也具有抗菌作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b560/9836105/7d1bf6ddbdf3/JAPTR-13-88-g001.jpg

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