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来自海洋放线菌属菌株的胞外聚合物及其抗氧化活性。

Extracellular polymeric substances from marine actinobacterium of sp. and their antioxidant activity.

作者信息

George Rinki Susan, Sivaperumal Pitchiah, Roy Anitha

机构信息

Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

Marine Biomedical Research Lab and Environmental Toxicology Unit, Cellular and Molecular Research Centre, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

出版信息

J Adv Pharm Technol Res. 2022 Nov;13(Suppl 1):S80-S83. doi: 10.4103/japtr.japtr_335_22. Epub 2022 Nov 30.

Abstract

, Gram-positive bacteria are the largest phyla among the major species in the bacteria domain. sp. is one of the secondary metabolite-producing , and it has a comprehensive spectrum of antibacterial, antifungal, antitumor, antiviral, antiparasitic, diabetogenic anti-inflammatory, insecticidal, inhibitory of enzyme, antioxidant, and other biological activities. The objective of the study is to assess the antioxidant activity of the sp. producing extracellular polymeric substances (EPSs). Enumeration and isolation of from sediment samples are done. The marine , sp. are identified by melanoid pigments and other chemotaxonomical characteristics. EPS is produced from the potential marine and their components are estimated. The total antioxidant value is found for the EPS. The antioxidant activity of the ascorbic acid equivalent which was 142.65 μg/ml was equivalent to 150 μg/ml of the total antioxidant activity of the EPS produced. The role of different antioxidants and the action in different diseases were challenged since they could act as many mechanisms such as reducing power, providing hydrogen to radicals, and scavenging activity (free radical). To conclude, the potent antioxidant activity was obtained from sp. producing extracellular substances. These extracts might bear anticancer metabolites and are considered a potent anticancer drug.

摘要

革兰氏阳性菌是细菌域主要物种中最大的门类。[具体菌种名称]属是产生次级代谢产物的属之一,它具有广泛的抗菌、抗真菌、抗肿瘤、抗病毒、抗寄生虫、抗糖尿病抗炎、杀虫、酶抑制、抗氧化及其他生物活性。本研究的目的是评估产生胞外聚合物(EPSs)的[具体菌种名称]属的抗氧化活性。对沉积物样本中的[具体菌种名称]属进行计数和分离。通过黑色素等化学分类特征鉴定海洋[具体菌种名称]属。从潜在的海洋[具体菌种名称]属产生EPS,并对其成分进行估算。测定EPS的总抗氧化值。发现抗坏血酸当量为142.65μg/ml时的抗氧化活性相当于所产生的EPS总抗氧化活性150μg/ml。不同抗氧化剂的作用以及在不同疾病中的作用受到质疑,因为它们可通过多种机制发挥作用,如还原能力、为自由基提供氢以及清除活性(自由基)。总之,从产生胞外物质的[具体菌种名称]属获得了强大的抗氧化活性。这些提取物可能含有抗癌代谢物,被认为是一种有效的抗癌药物。

相似文献

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Antioxidant activities from melanin pigment produced by marine actinobacterium of species.海洋放线菌产生的黑色素的抗氧化活性。
J Adv Pharm Technol Res. 2022 Nov;13(Suppl 1):S84-S87. doi: 10.4103/japtr.japtr_338_22. Epub 2022 Nov 30.

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