Liu Xuda, Wang Haiying, Liu Bingchen, Qi Zhipeng, Li Jiashuo, Xu Bin, Liu Wei, Xu Zhaofa, Deng Yu
Department of Public Health, China Medical University, Shenyang, China.
Front Cell Dev Biol. 2021 Sep 10;9:681238. doi: 10.3389/fcell.2021.681238. eCollection 2021.
Eukaryotic messenger mRNAs contain many RNA methyl chemical modifications, in which N-methyladenosine (mA) plays a very important role. The modification process of RNA methylation is a dynamic reversible regulatory process that is mainly catalyzed by "Writer" mA methyltransferase, removed by "Eraser" mA demethylase, and recognized by the mA binding protein, thereby, linking mA modification with other mRNA pathways. At various stages of the life cycle, mA modification plays an extremely important role in regulating mRNA splicing, processing, translation, as well as degradation, and is associated with gametogenesis and fertility for both sexes. Normal gametogenesis is a basic guarantee of fertility. Infertility leads to trauma, affects harmony in the family and seriously affects the quality of life. We review the roles and mechanisms of RNA mA methylation modification in infertility and provide a potential target for infertility treatment, which can be used for drug development.
真核生物信使mRNA含有许多RNA甲基化化学修饰，其中N-甲基腺苷（mA）起着非常重要的作用。RNA甲基化修饰过程是一个动态可逆的调控过程，主要由“书写器”mA甲基转移酶催化，由“擦除器”mA去甲基化酶去除，并由mA结合蛋白识别，从而将mA修饰与其他mRNA途径联系起来。在生命周期的各个阶段，mA修饰在调节mRNA剪接、加工、翻译以及降解方面发挥着极其重要的作用，并且与两性的配子发生和生育能力有关。正常的配子发生是生育能力的基本保证。不孕症会导致创伤，影响家庭和谐，并严重影响生活质量。我们综述了RNA mA甲基化修饰在不孕症中的作用和机制，并提供了一个不孕症治疗的潜在靶点，可用于药物开发。
