具有可定制输入和输出功能的工程膜受体。
Engineered membrane receptors with customizable input and output functions.
机构信息
Department of Chemical and Biological Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, USA; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.
Center for Synthetic Biology, Northwestern University, Evanston, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, USA.
出版信息
Trends Biotechnol. 2023 Mar;41(3):276-277. doi: 10.1016/j.tibtech.2023.01.002. Epub 2023 Jan 14.
Morsut et al. reported a synthetic receptor system, based on the natural Notch receptor, with customizable input and output functions. Their work on advanced receptor design expands the reach of synthetic receptor systems. Incorporating new protein design tools with better-understood membrane biophysics will create the next generation of engineered receptors.
莫苏特等人报道了一种基于天然 Notch 受体的合成受体系统，具有可定制的输入和输出功能。他们在高级受体设计方面的工作扩展了合成受体系统的应用范围。将新的蛋白质设计工具与更深入理解的膜生物物理学相结合，将创造下一代工程受体。
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