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亚急性感染性心内膜炎致脑脓肿并脊髓髓内脓肿。

Intramedullary spinal cord abscess with brain abscess due to subacute infective endocarditis.

机构信息

Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

出版信息

BMC Neurol. 2023 Jan 16;23(1):18. doi: 10.1186/s12883-023-03050-8.

Abstract

BACKGROUND

Intramedullary spinal cord abscesses (ISCA) are rare, even more so in association with brain abscesses. Infective endocarditis is an uncommon cause of ISCA. In this case study, we report a patient with intramedullary abscesses and multiple brain abscesses due to subacute infective endocarditis.

CASE PRESENTATION

A 54-year-old man presented with a 7-day history of head and neck pain and numbness in both lower limbs. Intramedullary abscess combined with multiple brain abscesses was diagnosed based on blood culture, head and spinal magnetic resonance imaging (MRI), contrast-enhanced MRI, and magnetic resonance spectroscopy. Echocardiography revealed vegetations on the mitral valve and severe mitral regurgitation, which the authors believe was caused by subacute infective endocarditis. With ceftriaxone combined with linezolid anti-infective therapy, the patient's symptoms and imaging was improved during follow-up.

CONCLUSIONS

This case hopes to raise the vigilance of clinicians for ISCA. When considering a patient with an ISCA, it is necessary to complete blood culture, MRI of the brain and spinal cord, and echocardiography to further identify whether the patient also has a brain abscess and whether the cause is infective endocarditis.

摘要

背景

脊髓髓内脓肿(ISCA)很少见,与脑脓肿同时发生的情况更为罕见。感染性心内膜炎是 ISCA 的一个不常见病因。在本病例研究中,我们报告了一例因亚急性感染性心内膜炎引起脊髓脓肿和多发脑脓肿的患者。

病例介绍

一名 54 岁男性因头部和颈部疼痛以及双下肢麻木 7 天就诊。根据血液培养、头部和脊髓磁共振成像(MRI)、增强 MRI 和磁共振波谱检查,诊断为脊髓脓肿合并多发脑脓肿。超声心动图显示二尖瓣有赘生物和严重的二尖瓣反流,作者认为这是由亚急性感染性心内膜炎引起的。患者接受头孢曲松联合利奈唑胺抗感染治疗后,症状和影像学表现得到改善。

结论

本病例希望提高临床医生对 ISCA 的警惕性。当考虑 ISCA 患者时,有必要完成血培养、脑和脊髓 MRI 以及超声心动图检查,以进一步确定患者是否还患有脑脓肿以及病因是否为感染性心内膜炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac2a/9841633/ae915db599a9/12883_2023_3050_Fig1_HTML.jpg

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