Susanti Lina, Kwon Dohyoung, Ahn Jaesang, Seo Kangmoon, Kang Seonmi
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Korea.
Ilsan Animal Medical Center, Ilsan, Korea.
Vet Ophthalmol. 2023 Mar;26(2):169-175. doi: 10.1111/vop.13058. Epub 2023 Jan 16.
To describe blindness, initially presenting as a unilateral condition and diagnosed as sudden acquired retinal degeneration syndrome (SARDS).
One Dachshund and four Maltese dogs presented with unilateral blindness, for which the results of general ophthalmic examinations were insufficient to explain the blindness. All dogs were spayed females.
Intraocular pressures were normal, and the optical media of the eyes were clear. Fundus appearances of the initially blind eyes were within normal variations, with slightly attenuated retinal blood vessels in some cases when compared with the sighted contralateral eyes. Electroretinography (ERG) amplitudes of the affected eyes were flat and reduced in the contralateral-sighted eyes in four dogs. One dog underwent ERG after the blindness progressed bilaterally 8 days after initial presentation (despite topical steroid medication). Two dogs had no recheck visits, but phone call follow-ups reported bilateral blindness 3 months later in one dog. One dog received no medication and retained vision in the contralateral eye until the last follow-up (94 days later). One dog received systemic cyclosporine and steroid medications and maintained vision in the contralateral eye; however, regular ERG rechecks showed a trend of declining amplitude (448 days). In this dog, optical coherence tomography (OCT) showed different stages of disorganized retinal layers as well as different retinal thickness between the eyes.
Despite normal-looking fundi, ERG and OCT revealed different degrees of retinal changes between both eyes in this study. Eyes with vision might develop progressive blindness after a substantial amount of time in these presumed SARDS cases.
描述最初表现为单眼失明并被诊断为突然获得性视网膜变性综合征（SARDS）的情况。
一只腊肠犬和四只马尔济斯犬出现单眼失明，常规眼科检查结果不足以解释失明原因。所有犬均为绝育雌性。
眼压正常，眼内介质清晰。最初失明眼的眼底外观在正常变异范围内，与对侧视力正常的眼睛相比，部分病例视网膜血管略有变细。四只犬患眼的视网膜电图（ERG）波幅平坦，对侧视力正常眼的波幅降低。一只犬在初次就诊8天后失明进展为双眼失明（尽管使用了局部类固醇药物），之后进行了ERG检查。两只犬没有复诊，但通过电话随访得知，其中一只犬在3个月后出现双眼失明。一只犬未接受任何药物治疗，对侧眼直至最后一次随访（94天后）仍保留视力。一只犬接受了全身性环孢素和类固醇药物治疗，对侧眼维持了视力；然而，定期的ERG复查显示波幅有下降趋势（448天）。在这只犬中，光学相干断层扫描（OCT）显示视网膜层紊乱的不同阶段以及双眼视网膜厚度不同。
在本研究中，尽管眼底外观正常，但ERG和OCT显示双眼视网膜存在不同程度的变化。在这些疑似SARDS病例中，有视力的眼睛在相当长一段时间后可能会逐渐失明。
