Auten Candace R, Thomasy Sara M, Kass Philip H, Good Kathryn L, Hollingsworth Steven R, Maggs David J
Companion Animal Hospital, Mount Prospect, IL, 60056, USA.
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA.
Vet Ophthalmol. 2018 May;21(3):264-272. doi: 10.1111/vop.12504. Epub 2017 Aug 27.
To determine factors associated with sudden acquired retinal degeneration syndrome (SARDS) diagnosed within one referral population.
151 dogs diagnosed with SARDS.
Breed, age, sex, and body weight were compared between dogs with electroretinogram-confirmed SARDS and dogs presented to the UC Davis Veterinary Medical Teaching Hospital (UCD-VMTH) from 1991 to 2014.
SARDS was diagnosed in 151 dogs, representing 1.3% of dogs presented to the UCD-VMTH for ophthalmic disease. Although dogs of 36 breeds were affected, the Dachshund (n = 31, 21%), Schnauzer (16, 11%), Pug (11, 7%), and Brittany (5, 3%) were significantly overrepresented, and the Labrador Retriever (3, 2%) was significantly underrepresented vs. the reference population (P < 0.001). Median (range) age and body weight of affected vs. reference dogs were 8.9 (3-20) vs. 6.8 (0.1-26) years and 12.4 (2.8-52.7) vs. 22.3 (0.1-60) kg, respectively. Dogs 6-10 years of age and between 10-20 kg in body weight were significantly overrepresented in the SARDS population, while dogs <6 years of age were significantly underrepresented (P < 0.01). Spayed females (59% of affected dogs) were significantly overrepresented compared to the reference population, whereas intact females (1% of affected dogs) were significantly underrepresented.
Consistent with previous studies, smaller, middle-aged, spayed female dogs may be at increased risk of developing SARDS. Unlike previous studies, this is the first study comparing a variety of SARDS-affected breeds to a reference population. Potentially increased risk of SARDS in several breeds, particularly Dachshunds, suggests a familial factor that warrants further investigation using genetic techniques.
确定在一个转诊群体中被诊断为突发性获得性视网膜变性综合征（SARDS）的相关因素。
151只被诊断为SARDS的犬。
对1991年至2014年期间视网膜电图确诊为SARDS的犬与就诊于加州大学戴维斯分校兽医教学医院（UCD-VMTH）的犬在品种、年龄、性别和体重方面进行比较。
151只犬被诊断为SARDS，占因眼科疾病就诊于UCD-VMTH犬只的1.3%。虽然有36个品种的犬受到影响，但腊肠犬（n = 31，21%）、雪纳瑞犬（16只，11%）、哈巴犬（11只，7%）和不列塔尼猎犬（5只，3%）的占比显著过高，而拉布拉多寻回犬（3只，2%）的占比与参考群体相比显著过低（P < 0.001）。患犬与参考犬的年龄中位数（范围）分别为8.9（3 - 20）岁和6.8（0.1 - 26）岁，体重分别为12.4（2.8 - 52.7）千克和22.3（0.1 - 60）千克。6至10岁且体重在10至20千克之间的犬在SARDS群体中的占比显著过高，而年龄小于6岁的犬占比显著过低（P < 0.01）。绝育雌性犬（占患犬的59%）与参考群体相比占比显著过高，而未绝育雌性犬（占患犬的1%）占比显著过低。
与先前研究一致，体型较小、中年、绝育的雌性犬患SARDS的风险可能增加。与先前研究不同的是，这是第一项将多种受SARDS影响的品种与参考群体进行比较的研究。几个品种，特别是腊肠犬，患SARDS风险可能增加，这表明存在一个家族因素，值得使用遗传技术进行进一步研究。
