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Epidemiology and Disease Burden of Alcohol Associated Liver Disease.

作者信息

Aslam Aysha, Kwo Paul Y

机构信息

Stanford University School of Medicine, 430 Broadway, Pavilion C, 3rd Floor, Redwood City, CA 94063, USA.

出版信息

J Clin Exp Hepatol. 2023 Jan-Feb;13(1):88-102. doi: 10.1016/j.jceh.2022.09.001. Epub 2022 Sep 20.


DOI:10.1016/j.jceh.2022.09.001
PMID:36647400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9840073/
Abstract

Consumption of alcohol in excess leads to substantial medical, economic, and societal burdens. Approximately 5.3% of all global deaths may be attributed to alcohol consumption. Moreover, the burden of alcohol associated liver disease (ALD) accounts for 5.1% of all disease and injury worldwide. Alcohol use disorder (AUD) affects men more than women globally with significant years of life loss to disability in low, middle and well-developed countries. Precise data on global estimates of alcohol related steatosis, alcohol related hepatitis, and alcohol related cirrhosis have been challenging to obtain. In the United States (US), alcohol related steatosis has been estimated at 4.3% based on NHANES data which has remained stable over 14 years. However, alcohol-related fibrotic liver disease has increased over the same period. In those with AUD, the prevalence of alcohol related hepatitis has been estimated at 10-35%. Globally, the prevalence of alcohol-associated cirrhosis has been estimated at 23.6 million individuals for compensated cirrhosis and 2.46 million for those with decompensated cirrhosis. The contribution of ALD to global mortality and disease burden of liver related deaths is substantial. In 2016 liver disease related to AUD contributed to 50% of the estimated liver disease deaths for age groups 15 years and above. Data from the US report high cost burdens associated with those admitted with alcohol-related liver complications. Finally, the recent COVID-19 pandemic has been associated with marked increase in alcohol consumption worldwide and will likely increase the burden of ALD.

摘要

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本文引用的文献

[1]
The impact of the COVID lockdown on alcohol consumption in the Netherlands. The role of living arrangements and social isolation.

Drug Alcohol Depend. 2022-4-1

[2]
Student-, Study- and COVID-19-Related Predictors of Students' Smoking, Binge Drinking and Cannabis Use before and during the Initial COVID-19 Lockdown in The Netherlands.

Int J Environ Res Public Health. 2022-1-12

[3]
Changes in the dollar value of per capita alcohol, essential, and non-essential retail sales in Canada during COVID-19.

BMC Public Health. 2021-11-25

[4]
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PLoS One. 2021

[5]
Association of COVID-19 With New Waiting List Registrations and Liver Transplantation for Alcoholic Hepatitis in the United States.

JAMA Netw Open. 2021-10-1

[6]
The Pandemic Within the Pandemic: Unprecedented Rise in Alcohol-related Hepatitis During the COVID-19 Pandemic.

J Clin Gastroenterol. 2022-3-1

[7]
Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition.

World J Gastroenterol. 2021-9-14

[8]
Effects of the COVID-19 Mitigation Measures on Alcohol Consumption and Binge Drinking in College Students: A Longitudinal Survey.

Int J Environ Res Public Health. 2021-9-17

[9]
Alcohol Consumption during COVID among Women with an Existing Alcohol-Use Disorder.

Int J Environ Res Public Health. 2021-9-8

[10]
COVID-19 Aftershocks on Alcohol-Associated Liver Disease: An Early Cross-Sectional Report From the U.S. Epicenter.

Hepatol Commun. 2021-7

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