Rodríguez Melo Johan, Mammarella Florencia, Ariel Federico
Instituto de Agrobiotecnología del Litoral, CONICET, Universidad Nacional del Litoral, Colectora Ruta Nacional 168 km 0, 3000, Santa Fe, Argentina.
J Exp Bot. 2023 Apr 9;74(7):2323-2337. doi: 10.1093/jxb/erad023.
The impending need for increasing amounts of food for the world population poses enormous challenges to agriculture. Moreover, global warming has exacerbated abiotic and biotic stresses, accelerating the emergence of new pests and pathogens which threatens crop productivity. Therefore, the scientific community urgently needs to develop innovative solutions for sustainable agriculture, notably replacing synthetic pesticides by active and highly specific biomolecules for pest control. In this context, RNA-based technologies emerge as an outstanding genetically modified organism-free approach offering versatile solutions to boost productivity while conserving and harnessing the wide variety of local landraces. Here we review recent advances in the field, including RNA synthesis approaches and the development of the nanotechnology required for RNA stabilization and delivery, and we discuss the potential of RNA as the key molecule for versatile applications in the second green revolution.
全球人口对粮食需求的不断增加给农业带来了巨大挑战。此外，全球变暖加剧了非生物和生物胁迫，加速了新害虫和病原体的出现，威胁着作物生产力。因此，科学界迫切需要为可持续农业开发创新解决方案，特别是用活性和高度特异性的生物分子取代合成农药来控制害虫。在这种背景下，基于RNA的技术作为一种杰出的无转基因生物方法应运而生，它提供了多种解决方案，既能提高生产力，又能保护和利用各种当地地方品种。在此，我们综述了该领域的最新进展，包括RNA合成方法以及RNA稳定化和递送所需的纳米技术的发展，并讨论了RNA作为关键分子在第二次绿色革命中广泛应用的潜力。
