Shabbirahmed Asma Musfira, Sekar Rajkumar, Gomez Levin Anbu, Sekhar Medidi Raja, Hiruthyaswamy Samson Prince, Basavegowda Nagaraj, Somu Prathap
Department of Biotechnology, School of Agriculture and Biosciences, Karunya Institute of Technology and Sciences (Deemed-to-be University), Karunya Nagar, Coimbatore 641 114, Tamil Nadu, India.
Department of Chemistry, Karpaga Vinayaga College of Engineering and Technology, GST Road, Chinna Kolambakkam, Chengalpattu 603308, Tamil Nadu, India.
Biomimetics (Basel). 2023 Jan 2;8(1):16. doi: 10.3390/biomimetics8010016.
Regenerative medicine has received potential attention around the globe, with improving cell performances, one of the necessary ideas for the advancements of regenerative medicine. It is crucial to enhance cell performances in the physiological system for drug release studies because the variation in cell environments between in vitro and in vivo develops a loop in drug estimation. On the other hand, tissue engineering is a potential path to integrate cells with scaffold biomaterials and produce growth factors to regenerate organs. Scaffold biomaterials are a prototype for tissue production and perform vital functions in tissue engineering. Silk fibroin is a natural fibrous polymer with significant usage in regenerative medicine because of the growing interest in leftovers for silk biomaterials in tissue engineering. Among various natural biopolymer-based biomaterials, silk fibroin-based biomaterials have attracted significant attention due to their outstanding mechanical properties, biocompatibility, hemocompatibility, and biodegradability for regenerative medicine and scaffold applications. This review article focused on highlighting the recent advancements of 3D printing in silk fibroin scaffold technologies for regenerative medicine and tissue engineering.
再生医学已在全球范围内受到潜在关注，改善细胞性能是再生医学进步的必要理念之一。在药物释放研究的生理系统中提高细胞性能至关重要，因为体外和体内细胞环境的差异会在药物评估中形成一个循环。另一方面，组织工程是将细胞与支架生物材料整合并产生生长因子以再生器官的潜在途径。支架生物材料是组织生产的原型，在组织工程中发挥着重要作用。丝素蛋白是一种天然纤维聚合物，由于对组织工程中丝绸生物材料剩余物的兴趣日益浓厚，在再生医学中有重要用途。在各种基于天然生物聚合物的生物材料中，基于丝素蛋白的生物材料因其出色的机械性能、生物相容性、血液相容性和生物降解性，在再生医学和支架应用中受到了广泛关注。这篇综述文章重点介绍了3D打印在用于再生医学和组织工程的丝素蛋白支架技术方面的最新进展。
