Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Zhongshan Road, Yuexiu District, Guangzhou, 510000, PR China.
Shantou University Medical College, Shantou, 515000, PR China.
ACS Appl Bio Mater. 2021 Sep 20;4(9):6630-6646. doi: 10.1021/acsabm.1c00654. Epub 2021 Aug 9.
Musculoskeletal engineering has been considered as a promising approach to customize regenerated tissue (such as bone, cartilage, tendon, and ligament) via a self-healing performance. Recent advances have demonstrated the great potential of bioactive materials for regenerative medicine. Silk fibroin (SF), a natural polymer, is regarded as a remarkable bioactive material for musculoskeletal engineering thanks to its biocompatibility, biodegradability, and tunability. To improve tissue-engineering performance, silk fibroin is hybridized with other biomaterials to form silk-fibroin-based hybrid biomaterials, which achieve superior mechanical and biological performance. Herein, we summarize the recent development of silk-based hybrid biomaterials in musculoskeletal tissue with reasonable generalization and classification, mainly including silk fibroin-based inorganic and organic hybrid biomaterials. The applied inorganics are composed of calcium phosphate, graphene oxide, titanium dioxide, silica, and bioactive glass, while the polymers include polycaprolactone, collagen (or gelatin), chitosan, cellulose, and alginate. This article mainly focuses on the physical and biological performances both and study of several common silk-based hybrid biomaterials in musculoskeletal engineering. The timely summary and highlight of silk-fibroin-based hybrid biomaterials will provide a research perspective to promote the further improvement and development of silk fibroin hybrid biomaterials for improved musculoskeletal engineering.
肌肉骨骼工程被认为是一种很有前途的方法，可以通过自修复性能来定制再生组织（如骨骼、软骨、肌腱和韧带）。最近的进展表明，生物活性材料在再生医学中有巨大的潜力。丝素蛋白（SF）作为一种天然聚合物，由于其生物相容性、可生物降解性和可调节性，被认为是肌肉骨骼工程中的一种出色的生物活性材料。为了提高组织工程性能，丝素蛋白与其他生物材料杂交形成丝素蛋白基杂交生物材料，从而实现优异的机械性能和生物性能。在此，我们总结了近年来肌肉骨骼组织中基于丝素的杂交生物材料的最新发展，进行了合理的概括和分类，主要包括丝素基无机和有机杂交生物材料。应用的无机物包括磷酸钙、氧化石墨烯、二氧化钛、硅和生物活性玻璃，而聚合物包括聚己内酯、胶原蛋白（或明胶）、壳聚糖、纤维素和藻酸盐。本文主要关注肌肉骨骼工程中几种常见的基于丝素的杂交生物材料的物理和生物学性能以及研究。对丝素基杂交生物材料的及时总结和重点介绍，将为进一步提高和发展丝素杂交生物材料以改善肌肉骨骼工程提供研究视角。
