Hosseini Hossein, Ghavidel Farideh, Panahi Ghodratollah, Majeed Muhammed, Sahebkar Amirhossein
Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2023 Mar;37(3):1212-1224. doi: 10.1002/ptr.7730. Epub 2023 Jan 17.
Metabolic syndrome is characterized by multiple metabolic disorders. Several studies indicated that curcumin plus piperine could affect lipids profiles in various diseases. The present meta-analysis aims to assess the effect of curcumin plus piperine on lipid profiles in patients with MetS and associated disorders using a systematic review and meta-analysis of randomized controlled trials. Trials were searched by several electronic databases up to May 2022. The Comprehensive Meta-Analysis (CMA) version3 software carried out this systematic review and meta-analysis. Random-effects model and the inverse variance method were used to conduct the meta-analysis. We evaluated the publication bias and heterogeneity of all eligible studies. In addition, subgroup analyses and sensitivity assessments were performed to assess potential sources of heterogeneity. The combined results by the random-effects model demonstrated that curcumin plus piperine significantly decreased total cholesterol and LDL-C in patients suffering from metabolic syndrome. In comparison, the results of the overall effect size did not show any significant change in triglyceride concentrations. Our results were robust in sensitivity analysis and were not dependent on the dose of curcumin, the dose of piperine, and the duration of treatment. Our results showed that co-administration of piperine and curcumin supplementation improves the lipid profile in metabolic syndrome. However, further long-term RCTs are required to ascertain their clinical benefit.
代谢综合征的特征是多种代谢紊乱。多项研究表明，姜黄素加胡椒碱可影响各种疾病中的血脂水平。本荟萃分析旨在通过对随机对照试验进行系统评价和荟萃分析，评估姜黄素加胡椒碱对代谢综合征患者及其相关疾病血脂水平的影响。截至2022年5月，通过多个电子数据库检索试验。使用综合荟萃分析（CMA）版本3软件进行了这项系统评价和荟萃分析。采用随机效应模型和逆方差法进行荟萃分析。我们评估了所有符合条件研究的发表偏倚和异质性。此外，还进行了亚组分析和敏感性评估，以评估异质性的潜在来源。随机效应模型的合并结果表明，姜黄素加胡椒碱可显著降低代谢综合征患者的总胆固醇和低密度脂蛋白胆固醇。相比之下，总体效应大小的结果未显示甘油三酯浓度有任何显著变化。我们的结果在敏感性分析中很稳健，并且不依赖于姜黄素的剂量、胡椒碱的剂量和治疗持续时间。我们的结果表明，胡椒碱和姜黄素联合补充可改善代谢综合征患者的血脂水平。然而，需要进一步的长期随机对照试验来确定它们的临床益处。
