KIN：一种从低覆盖度古 DNA 推断亲缘关系的方法。

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Genome Biol. 2023 Jan 17;24(1):10. doi: 10.1186/s13059-023-02847-7.

Genetic kinship of ancient individuals can provide insights into their culture and social hierarchy, and is relevant for downstream genetic analyses. However, estimating relatedness from ancient DNA is difficult due to low-coverage, ascertainment bias, or contamination from various sources. Here, we present KIN, a method to estimate the relatedness of a pair of individuals from the identical-by-descent segments they share. KIN accurately classifies up to 3rd-degree relatives using at least 0.05x sequence coverage and differentiates siblings from parent-child pairs. It incorporates additional models to adjust for contamination and detect inbreeding, which improves classification accuracy.

古代个体的遗传亲缘关系可以提供有关其文化和社会等级制度的见解，并且与下游的遗传分析相关。然而，由于覆盖率低、确定偏差或来自各种来源的污染，从古代 DNA 估计亲缘关系很困难。在这里，我们提出了 KIN，这是一种使用他们共享的一致遗传片段来估计两个人之间亲缘关系的方法。KIN 使用至少 0.05x 的序列覆盖，可以准确地对高达 3 级亲属进行分类，并区分兄弟姐妹和父母子女对。它包含了额外的模型来调整污染和检测近亲繁殖，从而提高了分类准确性。