correctKin：一种优化的方法，可从低覆盖率的古代人类基因组推断至第四代表亲关系。
correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes.
机构信息
Department of Pediatrics, University of Szeged Albert Szent-Györgyi Medical Center Faculty of Medicine, Szeged, Hungary.
Department of Archaeogenetics, Institute of Hungarian Research, Budapest, Hungary.
出版信息
Genome Biol. 2023 Feb 28;24(1):38. doi: 10.1186/s13059-023-02882-4.
Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×-11.9×) using samples with known family relations and known/unknown population structure. Based on our results, correctKin allows for the reliable identification of relatedness up to the 4th degree from variable/low-coverage ancient or badly degraded forensic whole genome sequencing data.
利用低深度的古代序列进行亲属关系分析，其结果的不确定性很高，最高只能达到二级亲属关系。我们提出了一种新的、准确且快速的方法——correctKin，它可以利用低深度的古代数据估计亲属系数和置信区间。我们进行了模拟，并利用具有已知家族关系和已知/未知群体结构的样本，对不同基因组覆盖度（0.12×-11.9×）的现代和古代实验数据进行了验证。结果表明，correctKin 可以可靠地识别 4 级以内的亲缘关系，即使是在可变/低深度的古代或严重降解的法医全基因组测序数据中也是如此。
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