Peters Adam, Nys Charlotte, Leverett Dean, Wilson Iain, Van Sprang Patrick, Merrington Graham, Middleton Elizabeth, Garman Emily, Schlekat Christian
WCA Environment, Faringdon, UK.
Arche, Ghent, Belgium.
Environ Toxicol Chem. 2023 Mar;42(3):566-580. doi: 10.1002/etc.5561. Epub 2023 Feb 13.
Bioavailability has been taken into account in the regulation of nickel in freshwater ecosystems in Europe for over a decade; during that time a significant amount of new information has become available covering both the sensitivity of aquatic organisms to nickel toxicity and bioavailability normalization. The ecotoxicity database for chronic nickel toxicity to freshwater organisms has been updated and now includes 358 individual data points covering a total of 53 different species, all of which are suitable for bioavailability normalization to different water chemistry conditions. The bioavailability normalization procedure has also been updated to include updates to the bioavailability models that enable more sensitive water chemistry conditions to be covered by the model predictions. The updated database and bioavailability normalization procedure are applicable to more than 95% of regulated European surface water conditions and have been used to calculate site-specific criteria for a variety of different water chemistry scenarios, to provide an indication of how the sensitivity to nickel varies between different water types. The hazardous concentration for 5% of a species (HC5) values for this diverse selection of water types range from 1.6 to 36 µg L , clearly demonstrating the importance of accounting for nickel bioavailability in freshwaters. This updated database and bioavailability normalization procedure provide a robust basis for the derivation of regulatory thresholds for chronic nickel toxicity in freshwaters such as predicted no-effect concentrations and Environmental Quality Standards and are protective of the results of several mesocosm studies. Environ Toxicol Chem 2023;42:566-580. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
十多年来，欧洲在淡水生态系统中镍的监管中一直考虑生物有效性；在此期间，已获得了大量新信息，涵盖了水生生物对镍毒性的敏感性和生物有效性归一化。慢性镍对淡水生物毒性的生态毒理学数据库已更新，现在包括358个单独的数据点，涵盖总共53个不同物种，所有这些数据点都适用于针对不同水化学条件的生物有效性归一化。生物有效性归一化程序也已更新，包括对生物有效性模型的更新，使模型预测能够涵盖更敏感的水化学条件。更新后的数据库和生物有效性归一化程序适用于欧洲95%以上受监管的地表水条件，并已用于计算各种不同水化学情景下的特定场地标准，以表明对镍的敏感性在不同水类型之间如何变化。对于这种多样的水类型选择，5%物种的危险浓度（HC5）值范围为1.6至36μg/L，清楚地表明了在淡水中考虑镍生物有效性的重要性。这个更新后的数据库和生物有效性归一化程序为推导淡水慢性镍毒性的监管阈值（如预测无效应浓度和环境质量标准）提供了坚实的基础，并保护了多项中宇宙研究的结果。《环境毒理学与化学》2023年；42:566 - 580。© 2023作者。《环境毒理学与化学》由Wiley Periodicals LLC代表SETAC出版。
