Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P.R. China.
Angew Chem Int Ed Engl. 2023 Feb 6;62(7):e202210415. doi: 10.1002/anie.202210415. Epub 2023 Jan 17.
Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle-cell interactions, thus impeding further development. In this Scientific Perspective, the significance of CDT is clarified, the complex mechanism is deconstructed into primitive chemical and biological interactions, and the mechanism research directions based on the chemical kinetics and biological signaling pathways are discussed in detail. Moreover, beneficial outlooks are presented to enlighten the evolution of next-generation CDT. Hopefully, this Scientific Perspective can inspire new ideas and advances for CDT and provide a reference for breaking down the interdisciplinary barriers in the field of nanomedicine.
自将芬顿化学和纳米医学融合应用于癌症治疗的洞见提出以来，化学动力学治疗（CDT）领域取得了重大进展。然而，独特的肿瘤化学环境和不可避免的纳米颗粒-细胞相互作用使 CDT 的确切机制变得模糊不清，从而阻碍了其进一步发展。在这篇科学观点中，阐明了 CDT 的重要性，将复杂的机制分解为原始的化学和生物学相互作用，并详细讨论了基于化学动力学和生物信号通路的机制研究方向。此外，还提出了有益的展望，以启发下一代 CDT 的发展。希望本科学观点能够为 CDT 的发展带来新的思路和进展，并为纳米医学领域的跨学科障碍的突破提供参考。
