Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, P. R. China.
Int Wound J. 2023 Aug;20(6):2075-2081. doi: 10.1111/iwj.14076. Epub 2023 Jan 18.
To investigate the influencing factors of lower limb amputation in patients with diabetic foot ulcers. Patients with diabetic foot ulcers who were hospitalised in a tertiary general hospital in Guizhou Province from January 2019 to March 2022 were retrospectively collected. Sociological information of the general population, comorbidities, laboratory-related indicators, and information on the specialty situation, using univariate analysis and multifactor analysis, compared the influencing factors of amputation and non-amputee patients. A total of 205 patients with diabetic foot and 69 ampute patients (33.7%) were enrolled. The univariate analysis found that the decrease in HDL cholesterol levels was associated with the occurrence of lower extremity amputation, and logistic stepwise regression analysis showed that HDL-C was inversely correlated with the amputation rate of patients with diabetic foot ulcers, and the risk of amputation at low levels of HDL-C was 2.452 times higher than that of high-level HDL-C (95% CI: 1.105-5.846). Decreased HDL cholesterol levels are an independent predictor of amputation in patients with diabetic foot ulcers.
探讨糖尿病足溃疡患者下肢截肢的影响因素。
回顾性收集 2019 年 1 月至 2022 年 3 月在贵州省某三级综合医院住院的糖尿病足溃疡患者，记录一般人群的社会学信息、合并症、实验室相关指标及专科情况信息，采用单因素分析和多因素分析比较截肢和非截肢患者的影响因素。
共纳入 205 例糖尿病足患者和 69 例截肢患者（33.7%）。单因素分析发现，高密度脂蛋白胆固醇（HDL-C）水平降低与下肢截肢的发生有关，logistic 逐步回归分析显示，HDL-C 与糖尿病足溃疡患者的截肢率呈负相关，HDL-C 水平低的截肢风险是高水平 HDL-C 的 2.452 倍（95%CI：1.105~5.846）。
HDL 胆固醇水平降低是糖尿病足溃疡患者截肢的独立预测因子。
