Kakulas B A, Morrison I, Owen E T, Kitridou R
Department of Neuropathology, Royal Perth Hospital, University of Western Australia.
Clin Exp Neurol. 1987;23:23-9.
Minicore, multicore, core-targetoid and other ultrastructural lesions were found in the paraspinal muscles of patients with AS. The 10 patients studied, all men with AS, showed varying degrees of muscle fibre atrophy, Z band streaming, rod body formation, minicores, multicores and core-targetoid fibres. Central core disease, rod body myopathy, minicore and multicore diseases are recognized clinical entities within the congenital group of structural myopathies. Target fibres are believed to be a feature of reinnervation. It is also known that experimental tenotomy causes core-targetoid changes, rod bodies, minicores and multicores. Therefore, it seems possible that tension is a necessary stimulus for the correct programming of synthetic muscle enzymes, and without this disorganization occurs. It may also be assumed, but in this case for genetic reasons, that similar biochemical systems are disturbed in the group of congenital myopathies.
强直性脊柱炎（AS）患者的椎旁肌中发现了小核心、多核心、类核心靶及其他超微结构病变。研究的10例患者均为男性AS患者，表现出不同程度的肌纤维萎缩、Z带流、杆状体形成、小核心、多核心及类核心靶纤维。中央核心病、杆状体肌病、小核心和多核心病是先天性结构性肌病组中公认的临床实体。靶纤维被认为是再支配的一个特征。还已知实验性肌腱切断会导致类核心靶改变、杆状体、小核心和多核心。因此，张力似乎可能是合成肌肉酶正确编程的必要刺激因素，没有这种刺激就会发生紊乱。也可以假设，但在这种情况下是出于遗传原因，先天性肌病组中类似的生化系统受到了干扰。
