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Illuminating the mechanism of IL-6-mediated immunotherapy resistance.
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J Cell Physiol. 2019 Jun;234(6):8509-8521. doi: 10.1002/jcp.27782. Epub 2018 Nov 22.
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Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3.
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Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy.
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Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
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Soluble γc receptor attenuates anti-tumor responses of CD8 T cells in T cell immunotherapy.
Int J Cancer. 2018 Sep 1;143(5):1212-1223. doi: 10.1002/ijc.31402. Epub 2018 Apr 14.
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Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells.
Front Immunol. 2018 Sep 10;9:2041. doi: 10.3389/fimmu.2018.02041. eCollection 2018.
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The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy.
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Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review).
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Endothelial Stat3 activation promotes osteoarthritis development.
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本文引用的文献

1
CD8 T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.
Cell Rep Med. 2023 Jan 17;4(1):100878. doi: 10.1016/j.xcrm.2022.100878. Epub 2023 Jan 3.
2
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity.
Cancer Cell. 2022 May 9;40(5):509-523.e6. doi: 10.1016/j.ccell.2022.04.004.
3
Immunotherapy of COVID-19: Inside and Beyond IL-6 Signalling.
Front Immunol. 2022 Feb 22;13:795315. doi: 10.3389/fimmu.2022.795315. eCollection 2022.
6
Targeting the IL-6/JAK/STAT3 signalling axis in cancer.
Nat Rev Clin Oncol. 2018 Apr;15(4):234-248. doi: 10.1038/nrclinonc.2018.8. Epub 2018 Feb 6.
7
Revisiting STAT3 signalling in cancer: new and unexpected biological functions.
Nat Rev Cancer. 2014 Nov;14(11):736-46. doi: 10.1038/nrc3818.
8
IL-6 in inflammation, immunity, and disease.
Cold Spring Harb Perspect Biol. 2014 Sep 4;6(10):a016295. doi: 10.1101/cshperspect.a016295.

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