Department of Pathology, The Ohio State University, Columbus, OH, USA; Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, USA.
Cell Rep Med. 2023 Jan 17;4(1):100901. doi: 10.1016/j.xcrm.2022.100901.
Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.
胡塞尼等人报告称,IL-6-STAT3 信号通路会对细胞毒性 T 细胞的抗肿瘤功能产生负面影响。靶向 IL-6 信号通路可能会增强肿瘤对免疫检查点阻断疗法的反应。