Department of Laboratory Medicine, The First Hospital of Hebei Medical University, 89 Donggang Road, Shijiazhuang, 050031, China.
Department of Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
BMC Psychiatry. 2023 Jan 18;23(1):49. doi: 10.1186/s12888-023-04536-y.
Depression is a psychiatric disorder with global public health concerns. Although a number of risk factors have been identified for depression, there is no clear relationship between biochemistry and depression. In this study, we assessed whether depressive disorders are significantly associated with biochemical indicators.
Our study included 17,561 adults (age ≥ 18 years) participating in the 2009-2018 National Health and Nutrition Examination Survey (NHANES). The relationship between depression and biochemical and obesity indicators was analyzed by logistic regression.
As compared to the control group, men with depression showed significantly higher levels of gamma-glutamyl transferase, glucose, and triglycerides, and lower levels of albumin and total bilirubin. The depressed group had higher levels of alkaline phosphatase, bicarbonate, and sodium than the control group.
Several biochemical and anthropometric indices were associated with depression in this study. It would be interesting to further analyze their cause-effect relationship.
This study is a cross-sectional study. The population is less restricted and does not exclude people with diabetes, pregnancy, etc., so it is less significant for a specific population. Dietary information was not included, as diet plays an important role in many indicators.
抑郁症是一种具有全球公共卫生关注的精神障碍。尽管已经确定了许多抑郁症的风险因素，但生物化学与抑郁症之间没有明确的关系。在这项研究中，我们评估了抑郁障碍是否与生化指标显著相关。
我们的研究纳入了 17561 名成年人（年龄≥18 岁），参加了 2009-2018 年全国健康和营养调查（NHANES）。通过逻辑回归分析抑郁与生化和肥胖指标之间的关系。
与对照组相比，患有抑郁症的男性γ-谷氨酰转移酶、葡萄糖和甘油三酯水平显著升高，而白蛋白和总胆红素水平显著降低。与对照组相比，抑郁组的碱性磷酸酶、碳酸氢盐和钠水平更高。
本研究中，一些生化和人体测量指标与抑郁症相关。进一步分析它们的因果关系将很有趣。
本研究为横断面研究。该人群的限制较少，不排除糖尿病、妊娠等人群，因此对特定人群的意义较小。未纳入饮食信息，因为饮食对许多指标都有重要影响。
