Yao Qihuan, Chen Guozhong
Department of Health Management, School of Public Health, Hangzhou Normal University, Hangzhou, China.
Front Public Health. 2025 Jan 24;13:1472415. doi: 10.3389/fpubh.2025.1472415. eCollection 2025.
Chronic disease multimorbidity is influenced by multiple factors, but with little knowledge on the impact of biochemical indicators. This study aims to investigate the prevalence of multimorbidity of chronic diseases among older adult individuals in the community, as well as the factors related to biochemical indicators associated with chronic disease multimorbidity.
The study included 19,624 older adult individuals aged 60 and above in Jindong District, Jinhua City, Zhejiang Province, China. Participants completed a national standardized older adult health examination in the community. Chi-square tests and logistic regression were employed to evaluate the potential factors of biochemical indicators related to multimorbidity of chronic diseases.
The multimorbidity rate of chronic diseases in older adult patients is 70.3%. Each chronic disease coexists with one or more other chronic diseases in over 75% of cases. Among the biochemical indicators, hemoglobin (Hb) (OR = 1.46, 95%CI: 1.13-1.90), white blood cell count (WBC) (OR = 1.25, 95%CI: 1.02-1.54), red blood cell count (RBC) (OR = 1.36, 95%CI: 1.10-1.69), urinary protein (U-PRO) (OR = 1.10, 95%CI: 1.02-1.19), urinary glucose (U-GLU) (OR = 1.44, 95%CI: 1.23-1.67), alanine aminotransferase (ALT) (OR = 1.71, 95%CI: 1.39-2.10), aspartate aminotransferase (AST) (OR = 1.22, 95%CI: 1.05-1.41), creatinine (Cr) (OR = 1.28, 95%CI: 1.16-1.42), uric acid (UA) (OR = 1.36, 95%CI: 1.22-1.51), total cholesterol (TC) (OR = 1.76, 95%CI: 1.59-1.95), triglycerides (TG) (OR = 2.63, 95%CI: 2.46-2.82), low-density lipoprotein cholesterol (LDL-C) (OR = 1.84, 95%CI: 1.60-2.11), high-density lipoprotein cholesterol (HDL-C) (OR = 10.99, 95%CI: 8.12-14.90), and fasting blood glucose (FBG) (OR = 1.89, 95%CI: 1.74-2.05) are associated with the risk of multimorbidity of chronic diseases ( < 0.05). Among these, lipid parameters demonstrated the strongest associations with multimorbidity risk, with low HDL-C showing an 11-fold increase and elevated TG a 2.63-fold increase.
This study found that the prevalence of multimorbidity among older adult individuals in this region reached 70.3%. Multiple biochemical indicators were significantly associated with multimorbidity, particularly lipid parameters (low HDL-C and elevated TG), glucose parameters (elevated FBG and positive U-GLU), liver function (elevated ALT), and hemoglobin levels. These findings provide important evidence for research on factors associated with multimorbidity in the older adult population.
慢性病共病受多种因素影响，但对生化指标的影响知之甚少。本研究旨在调查社区老年人群慢性病共病的患病率，以及与慢性病共病相关的生化指标因素。
本研究纳入了中国浙江省金华市金东区19624名60岁及以上的老年人。参与者在社区完成了全国标准化的老年健康检查。采用卡方检验和逻辑回归来评估与慢性病共病相关的生化指标的潜在因素。
老年患者慢性病共病率为70.3%。超过75%的病例中，每种慢性病都与一种或多种其他慢性病共存。在生化指标中，血红蛋白（Hb）（OR = 1.46，95%CI：1.13 - 1.90）、白细胞计数（WBC）（OR = 1.25，95%CI：1.02 - 1.54）、红细胞计数（RBC）（OR = 1.36，95%CI：1.10 - 1.69）、尿蛋白（U - PRO）（OR = 1.10，95%CI：1.02 - 1.19）、尿葡萄糖（U - GLU）（OR = 1.44，95%CI：1.23 - 1.67）、谷丙转氨酶（ALT）（OR = 1.71，95%CI：1.39 - 2.10）、谷草转氨酶（AST）（OR = 1.22，95%CI：1.05 - 1.41）、肌酐（Cr）（OR = 1.28，95%CI：1.16 - 1.42）、尿酸（UA）（OR = 1.36，95%CI：1.22 - 1.51）、总胆固醇（TC）（OR = 1.76，95%CI：1.59 - 1.95）、甘油三酯（TG）（OR = 2.63，95%CI：2.46 - 2.82）、低密度脂蛋白胆固醇（LDL - C）（OR = 1.84，95%CI：1.60 - 2.11）、高密度脂蛋白胆固醇（HDL - C）（OR = 10.99，95%CI：8.12 - 14.90）和空腹血糖（FBG）（OR = 1.89，95%CI：1.74 - 2.05）与慢性病共病风险相关（P < 0.05）。其中，血脂参数与共病风险的关联最强，低HDL - C使共病风险增加11倍，高TG使共病风险增加2.63倍。
本研究发现该地区老年人群共病患病率达70.3%。多种生化指标与共病显著相关，尤其是血脂参数（低HDL - C和高TG）、血糖参数（高FBG和尿葡萄糖阳性）、肝功能（高ALT）和血红蛋白水平。这些发现为老年人群共病相关因素的研究提供了重要证据。
