长期戒烟对早期声门型喉癌患者新发声门型喉癌事件的影响。
Long-term impact of smoking cessation on new glottic cancer events in patients with early glottic cancer.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi-do, Republic of Korea.
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea.
出版信息
Acta Otorhinolaryngol Ital. 2022 Dec;42(6):525-530. doi: 10.14639/0392-100X-N1917.
OBJECTIVE
Patients with early glottic cancer sometimes exhibit new glottic cancer events after 5 years. This study aimed to analyse the patterns and risk factors of new glottic cancer events in patients with early glottic cancer 5 years after initial treatment.
METHODS
In total, 209 patients were included in this study. Age, sex, T stage, anterior commissure involvement, smoking pattern and treatment modality were retrospectively analysed.
RESULTS
The median follow-up was 91 (range, 60-266) months. The median time for the occurrence of new glottic cancer events was 97 (range, 61-199) months. New glottic cancer events occurred 5 years after initial treatment in 16 (7.6%) patients, among whom 12 (75.0%) had new glottic cancer event lesions overlapping with initial lesions. Smoking cessation after treatment was significantly correlated with fewer new glottic cancer events after 5 years.
CONCLUSIONS
New glottic cancer events occurring 5 years after initial treatment in patients with early glottic cancer are not negligible. In particular, if smoking is continued after treatment, these patients can experience new glottic cancer events even after 5 years.
目的
早期声门癌患者在治疗后 5 年内有时会出现新的声门癌事件。本研究旨在分析初始治疗后 5 年时早期声门癌患者新发声门癌事件的模式和危险因素。
方法
共纳入 209 例患者。回顾性分析年龄、性别、T 分期、前连合受累、吸烟模式和治疗方式。
结果
中位随访时间为 91（范围 60-266）个月。新发声门癌事件的中位时间为 97（范围 61-199）个月。16 例（7.6%）患者在初始治疗 5 年后发生新发声门癌事件，其中 12 例（75.0%）的新发声门癌事件病变与初始病变重叠。治疗后戒烟与 5 年后新发声门癌事件减少显著相关。
结论
初始治疗后 5 年内发生的早期声门癌患者新发声门癌事件不可忽视。特别是，如果治疗后继续吸烟，这些患者即使在 5 年后也会发生新的声门癌事件。
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