Çakan Zeliha Kübra, Çakan Doğan, Yener Sevda, Çevik Haluk, Güçlü Fatma Şevval, Cansız Harun, Yener Haydar Murat
Division of Oncology, Department of Internal Medicine Istanbul University-Cerrahpaşa Istanbul Turkey.
Department of Otorhinolaryngology Istanbul University-Cerrahpaşa Istanbul Turkey.
Laryngoscope Investig Otolaryngol. 2025 Sep 13;10(5):e70207. doi: 10.1002/lio2.70207. eCollection 2025 Oct.
This study aimed to identify factors associated with continued smoking before and after treatment in laryngeal cancer (LC) patients.
This retrospective study included 108 patients, evenly distributed into three groups based on primary treatment: radiotherapy (RT)/chemoradiotherapy, transoral laser surgery (TOLS), and open-partial laryngectomy (OPL). Patients who remained abstinent from smoking for at least 6 months at the 1st year were accepted as ex-smokers. The relationship between patients' smoking status and demographic characteristics, disease- and treatment-related parameters, and data obtained via self-questionnaires at pre-treatment, the 1st month, and 1st year post-treatment follow-ups was analyzed statistically.
Patient age, education level, smoking intensity, perceived disease seriousness, importance of smoking cessation, information satisfaction, pre-treatment quality of life (QoL), and treatment method differ between LC patients who quit and those who continue smoking. Potential negative predictors for pre-treatment cessation and ex-smoker status include advanced age and age > 64.5 years, lower education level, advanced and > 47 pack-years smoking consumption, low perceived disease seriousness, low importance on cessation, poor pre-treatment QoL, and less invasive treatment. Notably, cessation before treatment might be the strongest predictor of being an ex-smoker, with an OR of 47.6 ( < 0.05).
This study identified the potential predictors of smoking cessation in the post-diagnosis period, and might facilitate the detection of high-risk patients who need intensive smoking cessation interventions.
Level 3.
本研究旨在确定喉癌（LC）患者治疗前后持续吸烟的相关因素。
这项回顾性研究纳入了108例患者，根据初始治疗方法平均分为三组：放射治疗（RT）/同步放化疗、经口激光手术（TOLS）和开放性部分喉切除术（OPL）。在第1年至少6个月不吸烟的患者被视为戒烟者。对患者的吸烟状况与人口统计学特征、疾病和治疗相关参数，以及在治疗前、治疗后第1个月和第1年随访时通过自填问卷获得的数据之间的关系进行了统计学分析。
戒烟和继续吸烟的LC患者在年龄、教育水平、吸烟强度、感知到的疾病严重程度、戒烟的重要性、信息满意度、治疗前生活质量（QoL）和治疗方法方面存在差异。治疗前戒烟和成为戒烟者的潜在负性预测因素包括高龄和年龄>64.5岁、教育水平较低、吸烟量≥47包年、感知到的疾病严重程度较低、对戒烟的重视程度较低、治疗前QoL较差以及治疗侵入性较小。值得注意的是，治疗前戒烟可能是成为戒烟者的最强预测因素，比值比为47.6（P<0.05）。
本研究确定了诊断后戒烟的潜在预测因素，并可能有助于发现需要强化戒烟干预的高危患者。
3级。
