Hu Yiqiang, Xiong Yuan, Tao Ranyang, Xue Hang, Chen Lang, Lin Ze, Panayi Adriana C, Mi Bobin, Liu Guohui
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, Hubei Province, China.
Biomater Transl. 2022 Sep 28;3(3):188-200. doi: 10.12336/biomatertransl.2022.03.003. eCollection 2022.
Diabetic wounds are a common complication in diabetes patients. Due to peripheral nerve damage and vascular dysfunction, diabetic wounds are prone to progress to local ulcers, wound gangrene and even to require amputation, bringing huge psychological and economic burdens to patients. However, the current treatment methods for diabetic wounds mainly include wound accessories, negative pressure drainage, skin grafting and surgery; there is still no ideal treatment to promote diabetic wound healing at present. Appropriate animal models can simulate the physiological mechanism of diabetic wounds, providing a basis for translational research in treating diabetic wound healing. Although there are no animal models that can fully mimic the pathophysiological mechanisms of diabetic wounds in humans, it is vital to explore animal simulation models used in basic research and preclinical studies of diabetic wounds. In addition, hydrogel materials are regarded as a promising treatment for diabetic wounds because of their good antimicrobial activity, biocompatibility, biodegradation and appropriate mechanical properties. Herein, we review and discuss the different animal models used to investigate the pathological mechanisms of diabetic wounds. We further discuss the promising future application of hydrogel biomaterials in diabetic wound healing.
糖尿病伤口是糖尿病患者常见的并发症。由于周围神经损伤和血管功能障碍，糖尿病伤口容易发展为局部溃疡、伤口坏疽，甚至需要截肢，给患者带来巨大的心理和经济负担。然而，目前糖尿病伤口的治疗方法主要包括伤口辅料、负压引流、皮肤移植和手术；目前仍没有促进糖尿病伤口愈合的理想治疗方法。合适的动物模型可以模拟糖尿病伤口的生理机制，为治疗糖尿病伤口愈合的转化研究提供依据。尽管没有动物模型能够完全模拟人类糖尿病伤口的病理生理机制，但探索用于糖尿病伤口基础研究和临床前研究的动物模拟模型至关重要。此外，水凝胶材料因其良好的抗菌活性、生物相容性、生物降解性和适当的机械性能，被视为治疗糖尿病伤口的一种有前景的材料。在此，我们回顾并讨论了用于研究糖尿病伤口病理机制的不同动物模型。我们进一步讨论了水凝胶生物材料在糖尿病伤口愈合中未来有前景的应用。
