Wu Haonan, Wu Yumeng, Cui Zhe, Hu Liandong
Key Laboratory of Pharmaceutical Quality Control of Hebei Province, School of Pharmaceutical Sciences, Hebei University, Baoding, China.
Crit Rev Food Sci Nutr. 2024 Jun;64(18):6361-6379. doi: 10.1080/10408398.2023.2168249. Epub 2023 Jan 19.
Lycopene is a promising biological functional component with various biological activities and excellent pharmacological activities. However, its low water solubility and stability lead to low oral bioavailability, which limits its edible and medicinal research. Then, it is necessary to explore effective methods to protect lycopene from destruction and further exploit its potential benefits. The absorption of lycopene in vivo is affected by solubility, stability, isomer type, emulsifying ability, difficulty in forming micelles in vivo, and interaction with food components. Emulsions, pickering emulsions, micelles, liposomes, bigels, beasds, solid dispersions, microcapsules, nanoparticles, electrospinning and other drug delivery systems can be used as good strategies to improve the stability and bioavailability of lycopene. In this paper, the absorption process of lycopene in vivo and the factors affecting its bioavailability were discussed, and the preparation strategies for improving the stability, bioavailability, and health benefits of lycopene were reviewed, to provide some clues and references for the full utilization of lycopene in the field of health. However, there are still various unresolved mysteries regarding the metabolism of lycopene. The safety and in vivo studies of various preparations should be further explored, and the above technologies also face the challenge of industrial production.
番茄红素是一种具有多种生物活性和优异药理活性的很有前景的生物功能成分。然而，其低水溶性和稳定性导致口服生物利用度低，这限制了其在食用和药用方面的研究。因此，有必要探索有效的方法来保护番茄红素不被破坏，并进一步挖掘其潜在益处。番茄红素在体内的吸收受溶解度、稳定性、异构体类型、乳化能力、在体内形成胶束的难度以及与食物成分的相互作用影响。乳液、皮克林乳液、胶束、脂质体、双凝胶、珠子、固体分散体、微胶囊、纳米颗粒、静电纺丝等药物递送系统可作为提高番茄红素稳定性和生物利用度的良好策略。本文讨论了番茄红素在体内的吸收过程及其生物利用度的影响因素，并综述了提高番茄红素稳定性、生物利用度和健康益处的制备策略，为番茄红素在健康领域的充分利用提供一些线索和参考。然而，关于番茄红素的代谢仍存在各种未解决的谜团。各种制剂的安全性和体内研究应进一步探索，上述技术也面临着工业化生产的挑战。
