钯催化2-三氟甲基-1,3-烯炔向多取代共轭二烯的区域选择性羰基化反应
Palladium-Catalyzed Regioselective Carbonylation of 2-Trifluoromethyl-1,3-enynes to Multisubstituted Conjugated Dienes.
作者信息
Kuai Chang-Sheng, Teng Bing-Hong, An Da-Lie, Zhao Yingying, Wu Xiao-Feng
机构信息
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Org Lett. 2023 Feb 3;25(4):682-687. doi: 10.1021/acs.orglett.2c04331. Epub 2023 Jan 19.
In this communication, a palladium-catalyzed regio- and stereoselective carbonylation of 2-trifluoromethyl-1,3-enynes to afford multisubstituted conjugated dienes has been realized. This protocol features excellent regio- and exclusive ()-stereoselectivity and a broad substrate scope with both amines and alcohols as the suitable reaction partners and has shown promising functional group tolerance.
在本通讯中，已实现了钯催化的2-三氟甲基-1,3-烯炔的区域和立体选择性羰基化反应，以得到多取代共轭二烯。该方法具有出色的区域选择性和专一的（）-立体选择性，底物范围广泛，胺和醇均为合适的反应伙伴，并且显示出良好的官能团耐受性。
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