Palladium-Catalyzed Intermolecular Tandem Difunctional Carbonylation of 1,3-Enynes: Synthesis of Fluoroalkylated Butenolides.

A palladium-catalyzed tandem difunctional carbonylation of 1,3-enynes with fluoroalkyl halides and water has been developed, enabling efficient one-step access to fluoroalkylated butenolides. The method exhibits a broad substrate scope, high chemo- and regioselectivity, and good functional group tolerance. Mechanistic studies support a Pd/Cu-cooperative pathway involving radical addition and carbonylative cyclization.