Consultant Pathologist, Agra, Uttar Pradesh, India.
Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India.
Indian J Pathol Microbiol. 2023 Jan-Mar;66(1):199-201. doi: 10.4103/ijpm.ijpm_449_22.
Reports on atypical human trypanosomiasis, caused by Trypanosoma lewisi, are rare and so far a total of 19 reports on human infection with animal trypanosomes, which includes nine cases from Trypanosoma lewisi exist. Trypanosoma lewisi, a Stercorarian trypanosoma of rats, is transmitted by the fecal contamination of the wound or the bite caused by rat flea Ceratophyllus fasciatus. We report here an atypical neonatal infection of T. lewisi in a 22-day-old infant from Agra. The infant presented with a history of high fever, poor appetite, and lethargy for 3 days. The hematological parameters were normal except for a low platelet count. A high C-reactive protein (CRP) concentration of 70.49 mg/L indicated marked inflammation. The Leishman-stained thin blood smears were microscopically positive for the hemoflagellate. Based on the morphological features and further confirmed by polymerase chain reaction (PCR) assay, the hemoflagellate was identified as T. lewisi. Symptomatic treatment and antibiotic therapy helped in an uneventful recovery of the patient.
关于由 Lewisi 锥虫引起的非典型人类锥虫病的报告很少，迄今为止，总共报告了 19 例人类感染动物锥虫的病例，其中包括 9 例来自 Lewisi 锥虫。Lewisi 锥虫是一种大鼠的 Stercorarian 锥虫，通过大鼠蚤 Ceratophyllus fasciatus 对伤口或咬伤的粪便污染传播。我们在此报告一例来自阿格拉的 22 天大婴儿的非典型新生儿 Lewisi 感染。该婴儿出现高热、食欲不振和昏睡 3 天的病史。除血小板计数低外，血液学参数正常。高 C-反应蛋白（CRP）浓度为 70.49mg/L 表明存在明显炎症。瑞氏染色的薄血涂片显示血鞭毛体呈显微镜阳性。根据形态特征，并进一步通过聚合酶链反应（PCR）检测证实，该血鞭毛体被鉴定为 Lewisi 锥虫。对症治疗和抗生素治疗有助于患者顺利康复。
