Braga P C, Fraschini F, Scaglione F, Scarpazza G, Schiavi M, Ventura P
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Chemotherapy. 1987;33(5):309-15. doi: 10.1159/000238514.
Cinoxacin is an antibacterial drug belonging to the quinolone class used in the treatment of urinary tract infections due to common gram-negative pathogens. Considering the high frequency of urinary tract infections in elderly people where aging represents a physiopathological condition frequently requiring an adjustment of the dosage regimen, the pharmacokinetic behaviour of cinoxacin (500 mg/12 h) in aged patients was investigated to find out if age-dependent differences may be established. The main differences detected were a shift to 4 h of the Tmax and a partly reduced clearance in comparison with data referred to younger people. On the other hand the findings showed that no accumulation occurred. High urinary concentrations of cinoxacin, exceeding the MICs for most urinary tract pathogens were found up to the 12th hour after administration.
西诺沙星是一种喹诺酮类抗菌药物，用于治疗由常见革兰氏阴性病原体引起的尿路感染。考虑到老年人尿路感染的高发病率，而衰老代表一种常需调整给药方案的生理病理状况，因此对老年患者中西诺沙星（500毫克/12小时）的药代动力学行为进行了研究，以确定是否存在年龄依赖性差异。检测到的主要差异是与年轻人的数据相比，达峰时间（Tmax）提前至4小时，清除率有所降低。另一方面，研究结果表明没有蓄积现象。给药后12小时内，西诺沙星在尿液中的浓度较高，超过了大多数尿路病原体的最低抑菌浓度（MIC）。
