Deng Qian, Zhu Yue, Zhang Mengmeng, Fei Aihua, Liang Jiaqi, Zheng Jinjin, Zhang Qingping, Cheng Tong, Ge Xia
Graduate College of Anhui University of Chinese Medicine, Hefei, China.
Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Endocr Connect. 2023 Feb 23;12(3). doi: 10.1530/EC-22-0419. Print 2023 Mar 1.
Diabetes is a complex metabolic disease. In recent years, diabetes and its chronic complications have become a health hotspot of global concern. It is very important to find promising therapeutic targets and directions. Ferroptosis is a new type of programmed cell death that is different from cell necrosis, apoptosis, and autophagy. Ferroptosis is mainly characterized by iron-dependent lipid peroxidation. With the reduction of the anti-oxidative capacity of cells, the accumulated reactive lipid oxygen species will cause oxidative cell death and lead to ferroptosis at lethal levels. Recent studies have shown that ferroptosis plays an important regulatory role in the initiation and development of diabetes, as well as various complications of diabetes. In this review, we will summarize new findings related to ferroptosis and diabetic complications and propose ferroptosis as a potential target for treating diabetic complications.
糖尿病是一种复杂的代谢性疾病。近年来，糖尿病及其慢性并发症已成为全球关注的健康热点。寻找有前景的治疗靶点和方向非常重要。铁死亡是一种新型的程序性细胞死亡，不同于细胞坏死、凋亡和自噬。铁死亡主要特征是铁依赖性脂质过氧化。随着细胞抗氧化能力的降低，积累的活性脂质氧会导致氧化性细胞死亡并在致死水平引发铁死亡。最近的研究表明，铁死亡在糖尿病的发生发展以及糖尿病的各种并发症中发挥着重要的调节作用。在本综述中，我们将总结与铁死亡和糖尿病并发症相关的新发现，并提出铁死亡作为治疗糖尿病并发症的潜在靶点。
