College of Life Sciences, Mudanjiang Medical University, Mudanjiang, China.
Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, China.
Front Endocrinol (Lausanne). 2023 Aug 3;14:1215292. doi: 10.3389/fendo.2023.1215292. eCollection 2023.
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the most serious and common diabetes-associated complications. DN and DR are all highly prevalent and dangerous global diseases, but the underlying mechanism remains to be elucidated. Ferroptosis, a relatively recently described type of cell death, has been confirmed to be involved in the occurrence and development of various diabetic complications. The disturbance of cellular iron metabolism directly triggers ferroptosis, and abnormal iron metabolism is closely related to diabetes. However, the molecular mechanism underlying the role of ferroptosis in DN and DR is still unclear, and needs further study. In this review article, we summarize and evaluate the mechanism of ferroptosis and its role and progress in DN and DR, it provides new ideas for the diagnosis and treatment of DN and DR.
糖尿病肾病（DN）和糖尿病视网膜病变（DR）是最严重和常见的糖尿病相关并发症。DN 和 DR 都是高度流行和危险的全球性疾病，但发病机制仍不清楚。铁死亡，一种相对较新描述的细胞死亡类型，已被证实参与了各种糖尿病并发症的发生和发展。细胞铁代谢的紊乱直接引发铁死亡，而异常的铁代谢与糖尿病密切相关。然而，铁死亡在 DN 和 DR 中的作用的分子机制尚不清楚，需要进一步研究。在这篇综述文章中，我们总结和评估了铁死亡的机制及其在 DN 和 DR 中的作用和进展，为 DN 和 DR 的诊断和治疗提供了新的思路。
