Interventional Radiology, St George Private Hospital, Sydney, NSW, Australia.
St George and Sutherland Clinical School, St George Hospital, University of NSW, Sydney, NSW, Australia.
Cardiovasc Intervent Radiol. 2023 Nov;46(11):1439-1446. doi: 10.1007/s00270-022-03348-z. Epub 2023 Jan 18.
Vertebroplasty has emerged over the last 30 years as a common treatment for painful osteoporotic vertebral fractures. Patient selection and the time at which vertebroplasty is offered to the patient varies between centres and regions. Vertebroplasty has been studied in comparison to placebo intervention in five blinded trials. One such trial showed more benefit from vertebroplasty than placebo when the procedure was mostly performed within 3 weeks of fracture onset. Others showed no additional benefit from vertebroplasty compared to placebo when it was performed later in the natural history of the fracture. In this review, we examine data from blinded and open label randomised studies of vertebroplasty for evidence relating specifically to the use of early vertebroplasty for patients with severely painful acute osteoporotic fractures.
椎体成形术在过去的 30 年中已经成为治疗疼痛性骨质疏松性椎体骨折的常用方法。患者的选择和椎体成形术的提供时间在不同的中心和地区有所不同。已经有五项盲法试验对椎体成形术与安慰剂干预进行了比较研究。其中一项试验表明，在骨折发生后 3 周内进行大多数椎体成形术时，椎体成形术比安慰剂更有优势。而其他试验则表明，当在骨折自然病程的后期进行椎体成形术时，与安慰剂相比，椎体成形术没有额外的益处。在这篇综述中，我们检查了盲法和开放标签随机研究的数据，以寻找与早期椎体成形术治疗严重疼痛性急性骨质疏松性骨折患者相关的证据。
