新型抗阿米巴吖啶。II. 一系列9-吖啶酮和9-亚氨基吖啶的合成与DNA结合
New antiamebic acridines. II. Synthesis and DNA binding of a series of 9-acridanones and 9-iminoacridines.
作者信息
Sharples D, Barbe J, Galy A M, Galy J P
机构信息
Department of Pharmacy, University of Manchester, UK.
出版信息
Chemotherapy. 1987;33(5):347-54. doi: 10.1159/000238520.
PMID:3665633
Abstract
A series of novel 9-acridanones and 9-iminoacridines has been prepared and investigated by a number of spectroscopic techniques in order to determine the nature and extent of the binding of these compounds to DNA. Results are discussed with reference to antiamebic activity in vitro.
摘要
已经制备了一系列新型的9-吖啶酮和9-亚氨基吖啶，并通过多种光谱技术进行了研究，以确定这些化合物与DNA结合的性质和程度。结合体外抗阿米巴活性对结果进行了讨论。
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