地衣芽孢杆菌D-13产生的杀阿米巴素对福氏耐格里阿米巴的特性及生物活性

Gálvez A, Maqueda M, Cordovilla P, Martínez-Bueno M, Lebbadi M, Valdivia E

Department of Microbiology, Faculty of Sciences, University of Granada, Spain.

Antimicrob Agents Chemother. 1994 Jun;38(6):1314-9. doi: 10.1128/AAC.38.6.1314.

The strain Bacillus licheniformis D-13 produces three hydrophobic peptides (amoebicins d13-A, d13-B, and d13-C) that elicit antiamoebic activity against human-pathogenic and nonpathogenic species of Naegleria and have a broad spectrum of antibacterial activity. The three amoebicins have the same amino acid composition (three Asp, two Glu, two Val, and nine Leu residues) and molecular weight (1,870). Amoebicin d13-B causes lysis of amoebae through disorganization of the cell membrane. It also induces permeability to 86Rb and membrane disruption in asolectin vesicles.

地衣芽孢杆菌D-13菌株产生三种疏水肽（变形虫素d13-A、d13-B和d13-C），这些肽对致病和非致病的耐格里属物种具有抗变形虫活性，并且具有广谱抗菌活性。这三种变形虫素具有相同的氨基酸组成（三个天冬氨酸、两个谷氨酸、两个缬氨酸和九个亮氨酸残基）和分子量（1870）。变形虫素d13-B通过破坏细胞膜导致变形虫溶解。它还诱导86Rb对asolectin囊泡的通透性和膜破坏。