诺氟沙星与阿霉素联合应用的杀菌及抗肿瘤作用
Bactericidal and antineoplastic effect of combination of norfloxacin and adriamycin.
作者信息
Castelli M, Barbieri M L, Bertolini A, Bossa R, Galatulas I
机构信息
Department of Pharmacology, Chemotherapy and Toxicology, University of Milano, Italy.
出版信息
Chemotherapy. 1987;33(5):355-60. doi: 10.1159/000238521.
PMID:3665634
Abstract
Norfloxacin and adriamycin were tested alone and in combination for bactericidal activity against different strains of gram-negative bacteria. The antitumoral effect of a combination of norfloxacin and adriamycin was determined in mice bearing Ehrlich ascites carcinoma and in mice bearing P 388 leukemia. No interference with the antibacterial activity of norfloxacin or with the antitumoral activity of adriamycin was observed.
摘要
对诺氟沙星和阿霉素分别及联合用药针对不同革兰氏阴性菌菌株的杀菌活性进行了测试。在携带艾氏腹水癌的小鼠和携带P 388白血病的小鼠中测定了诺氟沙星与阿霉素联合用药的抗肿瘤效果。未观察到对诺氟沙星抗菌活性或阿霉素抗肿瘤活性的干扰。
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