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庆大霉素与阿霉素联合使用的杀菌及抗肿瘤作用

Bactericidal and antineoplastic effect of combination of gentamicin and adriamycin.

作者信息

Bossa R, Galatulas I, Perrone G

出版信息

Chemotherapy. 1981;27(5):350-3. doi: 10.1159/000238003.

DOI:10.1159/000238003
PMID:7021078
Abstract

Gentamicin and adriamycin were tested against eight strains of Proteus mirabilis: using the cellophane transfer technique, combinations of these antibiotics were screened for bactericidal activity. On mice bearing Ehrlich ascites carcinoma, the antitumoral effect of a combination of gentamicin and adriamycin was determined. Antagonism occurred with the combination in bactericidal activity and not in antitumoral activity.

摘要

对庆大霉素和阿霉素针对8株奇异变形杆菌进行了测试:采用玻璃纸转移技术,对这些抗生素的组合进行杀菌活性筛选。在患有艾氏腹水癌的小鼠身上,测定了庆大霉素和阿霉素组合的抗肿瘤效果。该组合在杀菌活性方面出现拮抗作用,但在抗肿瘤活性方面未出现。

相似文献

1
Bactericidal and antineoplastic effect of combination of gentamicin and adriamycin.庆大霉素与阿霉素联合使用的杀菌及抗肿瘤作用
Chemotherapy. 1981;27(5):350-3. doi: 10.1159/000238003.
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Bactericidal and antineoplastic effect of combination of norfloxacin and adriamycin.诺氟沙星与阿霉素联合应用的杀菌及抗肿瘤作用
Chemotherapy. 1987;33(5):355-60. doi: 10.1159/000238521.
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[The in vitro effects of cephalothin, gentamicin and their combination against Proteus mirabilis and Enterococci].头孢噻吩、庆大霉素及其联合用药对奇异变形杆菌和肠球菌的体外作用
Adv Clin Pharmacol. 1974;8:46-50.
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[In vitro bactericidal effect of cefotetan-aminoside combinations].头孢替坦-氨基糖苷类联合用药的体外杀菌作用
Pathol Biol (Paris). 1988 May;36(5):361-5.
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[Studies on the in vitro effects of cephalothin and gentamicin, alone and in combination, on proteus mirabilis and enterococci (author's transl)].头孢噻吩与庆大霉素单独及联合应用对奇异变形杆菌和肠球菌的体外作用研究(作者译)
Infection. 1975;3(2):83-8. doi: 10.1007/BF01641047.
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Bactericidal activity of tigemonam, alone and in combination with gentamicin.替吉莫南单独及与庆大霉素联合使用时的杀菌活性。
J Chemother. 1989 May;1 Suppl 2:45-8.
7
[Effects of cephalothin, gentamicin, and their combination on the bacterium Proteus mirabilis].[头孢噻吩、庆大霉素及其联合用药对奇异变形杆菌的影响]
Int J Clin Pharmacol. 1972 Nov;6(4):346-53.
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Development of resistance to adriamycin (NSC-123127) in Ehrlich ascites tumor in vivo.
Cancer Chemother Rep. 1972 Jun;56(3):321-6.
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[Sensitivity of clinical Proteus strains to antibiotics and their combinations].
Antibiotiki. 1978 May;23(5):424-8.
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In vitro sensitivity of Proteus organisms to gentamicin and sisomicin.
Chemotherapy. 1979;25(2):96-105. doi: 10.1159/000237829.

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