精神分裂症作为一种代谢性疾病。它的病因是什么？
Schizophrenia as metabolic disease. What are the causes?
机构信息
Clinical Science, Faculty of Medicine, Yarmouk University, Irbid, Jordan.
Forensic Medicine and Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
出版信息
Metab Brain Dis. 2023 Mar;38(3):795-804. doi: 10.1007/s11011-022-01147-6. Epub 2023 Jan 19.
Abstract
Schizophrenia (SZ) is a devastating neurodevelopmental disease with an accelerated ageing feature. The criteria of metabolic disease firmly fit with those of schizophrenia. Disturbances in energy and mitochondria are at the core of complex pathology. Genetic and environmental interaction creates changes in redox, inflammation, and apoptosis. All the factors behind schizophrenia interact in a cycle where it is difficult to discriminate between the cause and the effect. New technology and advances in the multi-dispensary fields could break this cycle in the future.
摘要
精神分裂症（SZ）是一种具有加速老化特征的破坏性神经发育疾病。代谢疾病的标准与精神分裂症的标准完全吻合。能量和线粒体的紊乱是复杂病理学的核心。遗传和环境相互作用导致氧化还原、炎症和细胞凋亡的变化。导致精神分裂症的所有因素都在一个循环中相互作用，很难区分因果关系。新技术和多领域的进展可能会在未来打破这个循环。
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