Central Michigan University College of Medicine, Central Michigan University, Mt Pleasant.
Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia.
JAMA Netw Open. 2023 Jan 3;6(1):e2251156. doi: 10.1001/jamanetworkopen.2022.51156.
Atherosclerotic cardiovascular disease (ASCVD) continues to be highly prevalent in the US. The 2013 American College of Cardiology and American Heart Association (ACC/AHA) treatment guidelines reevaluated evidence-based practices for reduction of ASCVD in men and women from high-quality randomized trials and meta-analyses recommending the use of statin therapy, aspirin prescription, and lifestyle counseling for adults with ASCVD. Population trends in secondary prevention strategies for patients with ASCVD among primary care settings is currently lacking, limiting ability to evaluate impact of guideline implementation.
To examine temporal and sociodemographic trends in secondary prevention strategies in patients with ASCVD between 2006 and 2016 in a nationally representative, ambulatory care database.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study analyzed data from the National Ambulatory Medical Care Survey (NAMCS), which is an annual survey conducted to represent the national US population and contains information on ambulatory office-based patient visits, including medical conditions, services provided, and demographic characteristics. Participants were adults aged 21 years and older with prevalent ASCVD identified via International Classification of Disease codes between 2006 and 2016. Data were extracted and analyzed in March 2021.
Data were separated by calendar year pre-2013 (2006 to 2013) and post-2013 (2014 to 2016). Outcomes included statin therapy, aspirin prescription, and lifestyle counseling (eg, nutrition, exercise, weight reduction) service provided at clinic visits.
There were 11 033 visits for adults with ASCVD, representing a weighted total of 275.3 million visits nationwide; 40.7% (112.1 million [weighted]) were women, 9.2% (25.4 million [weighted]) were Hispanic, 9.9% (19.0 million [weighted]) were non-Hispanic Black, 90.1% (172.7 million [weighted]) were non-Hispanic White, and 40.6% (112.1 million [weighted]) were from cardiology clinics. Of 11 033 patient visits, 5507 patients (49.9%) were prescribed statin therapy, 5165 patients (46.8%) were using aspirin, 2233 patients (20.2%) received lifestyle counseling. Statin therapy increased from 9.3 million individuals (45.3%) in 2006 to 14.9 million individuals (46.5%) in 2016, and aspirin prescriptions increased from 8.5 million individuals (41.3%) in 2006 to 15.2 individuals (47.5%) in 2016. Women were less likely than men to receive medications for secondary prevention: among women, 48.8 million (43.3%) received statins (vs 85.9 million men [52.7%]), 44.7 million (39.8%) received aspirin (vs 79.1 million men [48.5%]), and 25.7 million (22.9%) received lifestyle counseling services (vs 37.5 million men [23.0%]).
These findings suggest only modest increases in statin and aspirin prescription since 2006; however, lifestyle counseling use decreased in recent years. Women and Black patients continued to be less likely to receive secondary prevention ASCVD treatment. Adherence to guideline-directed secondary prevention recommendations remained low (less than 50%) in patients with ASCVD, especially with regards to lifestyle counseling, suggesting the need for more implementation research.
动脉粥样硬化性心血管疾病(ASCVD)在美国仍然高度流行。2013 年美国心脏病学会和美国心脏协会(ACC/AHA)治疗指南重新评估了高质量随机试验和荟萃分析推荐的针对男性和女性 ASCVD 的基于证据的实践,包括他汀类药物治疗、阿司匹林处方和 ASCVD 成人的生活方式咨询。目前缺乏初级保健环境中 ASCVD 患者二级预防策略的人群趋势,限制了评估指南实施影响的能力。
在一个全国代表性的门诊医疗保健数据库中,检查 2006 年至 2016 年期间 ASCVD 患者二级预防策略的时间和社会人口统计学趋势。
设计、地点和参与者:这项横断面研究分析了国家门诊医疗保健调查(NAMCS)的数据,该调查是一项年度调查,旨在代表美国全国人口,并包含有关门诊办公患者就诊的信息,包括医疗状况、提供的服务和人口特征。参与者为年龄在 21 岁及以上的成年人,通过 2006 年至 2016 年的国际疾病分类代码确定为 ASCVD。数据于 2021 年 3 月提取和分析。
数据分为 2013 年之前(2006 年至 2013 年)和 2013 年之后(2014 年至 2016 年)两个时期。结果包括在诊所就诊时提供的他汀类药物治疗、阿司匹林处方和生活方式咨询(如营养、运动、减肥)服务。
共有 11033 次 ASCVD 成人就诊,代表全国 27.5 亿次就诊的加权总数;40.7%(1121 亿美元[加权])为女性,9.2%(2540 亿美元[加权])为西班牙裔,9.9%(1900 亿美元[加权])为非西班牙裔黑人,90.1%(1727 亿美元[加权])为非西班牙裔白人,40.6%(1121 亿美元[加权])为心脏病学诊所就诊。在 11033 例患者就诊中,5507 例(49.9%)患者接受了他汀类药物治疗,5165 例(46.8%)患者使用了阿司匹林,2233 例(20.2%)患者接受了生活方式咨询。他汀类药物治疗从 2006 年的 930 万人(45.3%)增加到 2016 年的 1490 万人(46.5%),阿司匹林处方从 2006 年的 850 万人(41.3%)增加到 2016 年的 1520 万人(47.5%)。与男性相比,女性接受二级预防药物治疗的可能性较低:女性中,4880 万人(43.3%)接受他汀类药物治疗(与 8590 万男性[52.7%]相比),4470 万人(39.8%)接受阿司匹林治疗(与 7910 万男性[48.5%]相比),2570 万人(22.9%)接受生活方式咨询服务(与 3750 万男性[23.0%]相比)。
这些发现表明,自 2006 年以来,他汀类药物和阿司匹林的处方量仅略有增加;然而,近年来生活方式咨询的使用有所减少。女性和黑人患者接受 ASCVD 二级预防治疗的可能性仍然较低。ASCVD 患者二级预防推荐的依从性仍然较低(低于 50%),特别是在生活方式咨询方面,这表明需要更多的实施研究。