哺乳动物受精：精子 IZUMO1 介导融合和黏附吗？
Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?
机构信息
Department of Biology, Hull York Medical School, York Biomedical Research Institute, University of York , York, UK.
出版信息
J Cell Biol. 2023 Feb 6;222(2). doi: 10.1083/jcb.202301035. Epub 2023 Jan 19.
Abstract
The molecular mechanism of sperm-egg fusion is a long-standing mystery in reproduction. Brukman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207147) now provide evidence that the sperm surface protein IZUMO1, which is essential for mammalian fertilization, can induce membrane fusion in cultured cells.
摘要
精卵融合的分子机制一直是生殖领域的一个未解之谜。Brukman 及其同事（2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207147）现提供证据表明，对哺乳动物受精至关重要的精子表面蛋白 IZUMO1 可在培养细胞中诱导膜融合。
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本文引用的文献
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2
SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins.SPACA6 外显结构揭示了一个保守的配子融合相关蛋白超家族。
Commun Biol. 2022 Sep 17;5(1):984. doi: 10.1038/s42003-022-03883-y.
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Sperm Meets Egg: The Genetics of Mammalian Fertilization.精子遇见卵子：哺乳动物受精的遗传学。
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Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice.卵母细胞引发的精子IZUMO1二聚化促进小鼠精卵融合。
Nat Commun. 2015 Nov 16;6:8858. doi: 10.1038/ncomms9858.
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The challenges involved in elucidating the molecular basis of sperm-egg recognition in mammals and approaches to overcome them.阐明哺乳动物精卵识别分子基础所涉及的挑战及克服这些挑战的方法。
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Mechanisms of fertilization elucidated by gene-manipulated animals.基因操纵动物揭示的受精机制。
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