Department of Biology, Hull York Medical School, York Biomedical Research Institute, University of York , York, UK.
J Cell Biol. 2023 Feb 6;222(2). doi: 10.1083/jcb.202301035. Epub 2023 Jan 19.
The molecular mechanism of sperm-egg fusion is a long-standing mystery in reproduction. Brukman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207147) now provide evidence that the sperm surface protein IZUMO1, which is essential for mammalian fertilization, can induce membrane fusion in cultured cells.
精卵融合的分子机制一直是生殖领域的一个未解之谜。Brukman 及其同事（2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207147）现提供证据表明，对哺乳动物受精至关重要的精子表面蛋白 IZUMO1 可在培养细胞中诱导膜融合。
