微小RNA-124-3p介导精神分裂症和双相情感障碍之间共享的多基因风险。
miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder.
作者信息
Żurawek Dariusz, Turecki Gustavo
机构信息
Department of Psychiatry, Douglas Institute, McGill University, 6875 LaSalle Boulevard, Montreal, QC H4H 1R3, Canada.
Department of Psychiatry, Douglas Institute, McGill University, 6875 LaSalle Boulevard, Montreal, QC H4H 1R3, Canada.
出版信息
Neuron. 2023 Jan 18;111(2):144-146. doi: 10.1016/j.neuron.2022.12.024.
PMID:36657396
Abstract
In this issue of Neuron, Namkung et al. demonstrate that the microRNA miR-124-3p is associated with polygenic risk scores shared between schizophrenia and bipolar disorder and confers risk to behavioral alterations common to these two disorders through modulation of AMPA receptor neurotransmission.
摘要
在本期《神经元》杂志中，南宫等人证明，微小RNA miR - 124 - 3p与精神分裂症和双相情感障碍共有的多基因风险评分相关，并通过调节AMPA受体神经传递赋予这两种疾病共同的行为改变风险。
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