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AMPA受体在社会行为中的作用。

Roles of AMPA receptors in social behaviors.

作者信息

Xu Qi Wei, Larosa Amanda, Wong Tak Pan

机构信息

Douglas Hospital Research Centre, Montreal, QC, Canada.

Department of Psychiatry, McGill University, Montreal, QC, Canada.

出版信息

Front Synaptic Neurosci. 2024 Jul 11;16:1405510. doi: 10.3389/fnsyn.2024.1405510. eCollection 2024.

DOI:10.3389/fnsyn.2024.1405510
PMID:39056071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11269240/
Abstract

As a crucial player in excitatory synaptic transmission, AMPA receptors (AMPARs) contribute to the formation, regulation, and expression of social behaviors. AMPAR modifications have been associated with naturalistic social behaviors, such as aggression, sociability, and social memory, but are also noted in brain diseases featuring impaired social behavior. Understanding the role of AMPARs in social behaviors is timely to reveal therapeutic targets for treating social impairment in disorders, such as autism spectrum disorder and schizophrenia. In this review, we will discuss the contribution of the molecular composition, function, and plasticity of AMPARs to social behaviors. The impact of targeting AMPARs in treating brain disorders will also be discussed.

摘要

作为兴奋性突触传递中的关键参与者，α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPARs）有助于社会行为的形成、调节和表达。AMPAR修饰与攻击、社交能力和社会记忆等自然主义社会行为有关，但在以社会行为受损为特征的脑部疾病中也有发现。了解AMPARs在社会行为中的作用对于揭示治疗自闭症谱系障碍和精神分裂症等疾病中社会功能障碍的治疗靶点具有及时性。在这篇综述中，我们将讨论AMPARs的分子组成、功能和可塑性对社会行为的贡献。还将讨论靶向AMPARs在治疗脑部疾病中的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/deac362e24db/fnsyn-16-1405510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/dcadf6b2f14b/fnsyn-16-1405510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/ea76305ff96b/fnsyn-16-1405510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/deac362e24db/fnsyn-16-1405510-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/dcadf6b2f14b/fnsyn-16-1405510-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/ea76305ff96b/fnsyn-16-1405510-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d09/11269240/deac362e24db/fnsyn-16-1405510-g003.jpg

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Transl Psychiatry. 2023 Oct 25;13(1):329. doi: 10.1038/s41398-023-02626-9.
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Mol Neurobiol. 2024 Jan;61(1):167-174. doi: 10.1007/s12035-023-03560-z. Epub 2023 Aug 17.
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