Chen Weiling, Li Zeqi, Cheng Yujiao, Li Guijie, Li Jiaqi, Huang Linhua, Gu Qiuming, Wu Houjiu
Guangdong Lijinyou Agricultural Technology Co., Ltd, Meizhou, Guangdong, China.
Citrus Research Institute, Chinese Academy of Agricultural Sciences, Chongqing, China.
Nat Prod Res. 2023 Nov-Dec;37(23):3984-3993. doi: 10.1080/14786419.2023.2167203. Epub 2023 Jan 19.
The content of 4 6',7'-dihydroxybergamottin (DHB), bergamottin, isoimperatorin and epoxybergamottin of six pomelos produced in China were detected by High-performance liquid chromatography-diode array detection and their safety of related medicines was evaluated by inhibition of medium concentration (IC) of cytochrome oxidases CYP450-like. The results showed that the total content of the four furanocoumarins in these pomelo juices from high to low in order was Guanximi pomelo > Liangping pomelo > Pinghemi pomelo > grapefruit > Huyou > Shatian pomelo. The concentration of isoimperatorin in grapefruit, DHB, bergamottinand and isoimperatorin in Liangping, bergamottin and epoxybergamottin in Pinghemi and all the four furanocoumarins in Guanximi were exceeded the corresponding IC; although Huyou and Shatian contained some furanocoumarins, they did not exceed IC. Therefore, when taking drugs metabolised by CYP450-like enzymes, Guanximi, Liangping, Pinghemi, and grapefruit should be avoided to consume, but it is relatively safe to eat Huyou and Shatian.
采用高效液相色谱 - 二极管阵列检测法测定了中国产6种柚子中4种成分，即6',7'-二羟基佛手柑内酯（DHB）、佛手柑内酯、异欧前胡素和环氧佛手柑内酯的含量，并通过对细胞色素氧化酶CYP450类似物的半数抑制浓度（IC）来评估其相关药物的安全性。结果表明，这些柚子汁中4种呋喃香豆素的总含量由高到低依次为：琯溪蜜柚＞梁平柚＞平和蜜柚＞葡萄柚＞胡柚＞沙田柚。葡萄柚中的异欧前胡素、梁平柚中的DHB和异欧前胡素、平和蜜柚中的佛手柑内酯和环氧佛手柑内酯以及琯溪蜜柚中的4种呋喃香豆素含量均超过相应的IC；虽然胡柚和沙田柚含有一些呋喃香豆素，但未超过IC。因此，服用经CYP450类似酶代谢的药物时，应避免食用琯溪蜜柚、梁平柚、平和蜜柚和葡萄柚，但食用胡柚和沙田柚相对安全。
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