Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Pharm. 2023 Feb 25;633:122615. doi: 10.1016/j.ijpharm.2023.122615. Epub 2023 Jan 16.
Cutaneous leishmaniasis (CL) is a global public health issue. Conventional treatments have substantial costs, side effects, and parasite resistance. Due to easy application and inexpensive cost, topical treatment is the optimal approach for CL. It could be used alone or with systemic treatments. Electrospun fibers as drug release systems in treating skin lesions have various advantages such as adjustable drug release rate, maintaining appropriate humidity and temperature, gas exchange, plasticity at the lesion site, similarity with the skin extracellular matrix (ECM) and drug delivery with high efficiency. Hydrogels are valuable scaffolds in the treatment of skin lesions. The important features of hydrogels include preserving unstable drugs from degradation, absorption of wound secretions, high biocompatibility, improving the re-epithelialization of the wound and preventing the formation of scars. One of the issues in local drug delivery systems for the skin is the low permeability of drugs in the skin. Polymeric scaffolds that are designed as microneedle patches can penetrate the skin and overcome this challenge. Also, drug delivery using nanocarriers increases the effectiveness of drugs in lower and more tolerable doses and reduces the toxicity of drugs. The application of cell therapy in the treatment of parasitic and infectious diseases has been widely investigated. The complexity of leishmaniasis treatment requires identifying new treatment options like cell therapy to overcome the disease. Topics investigated in this study include drug delivery systems based on tissue engineering scaffolds, nanotechnology and cell therapy-based studies to reduce the complications of CL.
皮肤利什曼病（CL）是一个全球性的公共卫生问题。传统的治疗方法存在成本高、副作用大、寄生虫耐药等问题。由于易于应用和成本低廉，局部治疗是 CL 的最佳方法。它可以单独使用或与全身治疗一起使用。电纺纤维作为治疗皮肤损伤的药物释放系统具有许多优点，如可调节的药物释放率、维持适当的湿度和温度、气体交换、在病变部位的可塑性、与皮肤细胞外基质（ECM）的相似性以及高效的药物输送。水凝胶是治疗皮肤损伤的有价值的支架。水凝胶的重要特征包括保护不稳定的药物免受降解、吸收伤口分泌物、高生物相容性、促进伤口再上皮化和防止疤痕形成。皮肤局部药物递送系统的一个问题是药物在皮肤中的渗透性低。设计为微针贴片的聚合物支架可以穿透皮肤，克服这一挑战。此外，使用纳米载体进行药物输送可以提高药物在较低和更耐受剂量下的有效性，并降低药物的毒性。细胞疗法在寄生虫和传染病治疗中的应用已经得到了广泛的研究。利什曼病治疗的复杂性要求寻找新的治疗选择，如细胞疗法，以克服该疾病。本研究中探讨的主题包括基于组织工程支架的药物输送系统、纳米技术和基于细胞疗法的研究，以减少 CL 的并发症。
