From the University of Rochester Medical Center (N.S., S.E., J.A., S.P., S.M.), Rochester, New York
Sanjay Gandhi Postgraduate Institute of Medical Sciences (M.O.), Lucknow, Uttar Pradesh, India.
AJNR Am J Neuroradiol. 2023 Mar;44(3):236-246. doi: 10.3174/ajnr.A7762. Epub 2023 Jan 19.
PET with amino acid tracers provides additional insight beyond MR imaging into the biology of gliomas that can be used for initial diagnosis, delineation of tumor margins, planning of surgical and radiation therapy, assessment of residual tumor, and evaluation of posttreatment response. Hybrid PET MR imaging allows the simultaneous acquisition of various PET and MR imaging parameters in a single investigation with reduced scanning time and improved anatomic localization. This review aimed to provide neuroradiologists with a concise overview of the various amino acid tracers and a practical understanding of the clinical applications of amino acid PET MR imaging in glioma management. Future perspectives in newer advances, novel radiotracers, radiomics, and cost-effectiveness are also outlined.
正电子发射断层扫描（PET）与氨基酸示踪剂为胶质瘤的生物学特性提供了比磁共振成像（MR）更深入的了解，可以用于初始诊断、肿瘤边界的划定、手术和放疗计划、残留肿瘤的评估以及治疗后反应的评估。PET-MR 成像允许在单次检查中同时采集各种 PET 和 MR 成像参数，从而减少扫描时间并提高解剖定位的准确性。本综述旨在为神经放射科医生提供各种氨基酸示踪剂的简明概述，并对氨基酸 PET-MR 成像在胶质瘤管理中的临床应用有实际的了解。本文还概述了新进展、新型放射性示踪剂、影像组学和成本效益方面的未来展望。
