Gopinath C, Gibson W A
Huntingdon Research Centre, Cambridgeshire, England.
Environ Health Perspect. 1987 Aug;73:107-13. doi: 10.1289/ehp.8773107.
Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing recovery period. This report also gives the first recorded incidence of spontaneous mesovarian leiomyomas in the rat.
用两种化学性质不同的β-兴奋剂（沙丁胺醇和特布他林）对斯普拉格-道利大鼠进行长期治疗，导致了卵巢系膜平滑肌瘤的出现。同时给予β-阻滞剂普萘洛尔可预防沙丁胺醇诱导的这些肿瘤的发生。在停药后的44周恢复期内，沙丁胺醇诱导的卵巢系膜平滑肌瘤没有出现任何消退或进展。本报告还首次记录了大鼠自发性卵巢系膜平滑肌瘤的发生率。
