Guo Mengyu, Zhou Guoqiang, Liu Zhu, Liu Jing, Tang Jinglong, Xiao Yating, Xu Wenshi, Liu Ying, Chen Chunying
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; University of Chinese Academy Sciences, Beijing 100049, China.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 050011, China.
Sci Bull (Beijing). 2018 Jan 30;63(2):92-100. doi: 10.1016/j.scib.2017.11.018. Epub 2017 Nov 24.
Doxorubicin (DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly (lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin. DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration, the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity.
阿霉素（DOX）广泛应用于癌症治疗。然而，其应用有时会受到不良心脏毒性和给药途径的限制。在我们的研究中，我们制备了一种用于药物控释和局部治疗的局部可植入给药装置。核心区域由聚（乳酸-乙醇酸共聚物）和聚己内酯组成，而外壳区域由交联明胶组成。DOX被包裹在通过静电纺丝获得的核壳纳米纤维的核心区域。这种可植入给药装置被植入小鼠模型的黑色素瘤顶部，该装置显示出DOX控释曲线，对小鼠黑色素瘤生长具有持续且足够的局部浓度，副作用可忽略不计。与传统静脉给药相比，可植入装置允许精确的局部治疗，因此可以减少剂量、降低注射频率，并确保抗肿瘤疗效，同时对正常组织的副作用更低。使用同轴静电纺丝工艺，有望在不使用大剂量全身药物且将全身毒性降至最低的情况下，递送不同的疏水性或亲水性药物用于直接肿瘤局部特异性治疗。
